Different Genetic Features Associated With Hepatic Carcinogenesis
Recruitment status was: Recruiting
|Study Design:||Observational Model: Case Control
Time Perspective: Retrospective
|Official Title:||Identification of Survival-related microRNAs in Hepatocellular Carcinoma|
|Study Start Date:||February 2010|
|Estimated Study Completion Date:||July 2012|
|Estimated Primary Completion Date:||July 2012 (Final data collection date for primary outcome measure)|
tumor tissues of HCC patients
paired nontumor tissues of HCC patients
Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths in Taiwan. HCC normally develops as a consequence of underlying liver disease and is most often associated with cirrhosis. Surgical resection and liver transplantation are current best curative options to treat HCC. However, recurrence or metastasis is quite common in patients who have had a resection and survival rate is 30% to 40% at 5 years postoperatively.
MicroRNAs, small non-coding RNA, act as endogenous RNA interference by post-transcription regulation. Recent studies suggest that microRNAs may act as tumor suppressors or oncogenes and altered microRNA expression levels may play an important role in the cancer initiation and progression. Several studies, including ourselves, have shown that specific microRNAs are aberrantly expressed in malignant HCC tissues compared to normal counterpart. Although many microRNA profiling studies were done to diagnose hepatocarcinogenesis, data about prognostic significances for postsurgical survival are very limited. The main point of this study is to develop a predictive signature for postsurgical survival in HCC patients.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01247506
|National Taiwan University Hospital|
|Study Chair:||Po-Huang Lee, PhD||National Taiwan University Hospital|