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Exploratory Study Using Nanotechnology to Detect Biomarkers of Parkinson's Disease From Exhaled Breath

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01246336
First Posted: November 23, 2010
Last Update Posted: October 31, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Technion, Israel Institute of Technology
Information provided by (Responsible Party):
Ilana Schlesinger, Rambam Health Care Campus
  Purpose
Parkinson's disease is diagnosed clinically, because biomarkers that may help in diagnosis and differential diagnosis are not yet available. Exhaled breath testing may yield a "breath-print" that can be used to distinguish healthy and diseased states.

Condition Intervention
Parkinson's Disease Parkinsonism Other: collection of exhaled breath

Study Type: Observational
Study Design: Observational Model: Other
Time Perspective: Prospective
Official Title: Exploratory Study to Detect Volatile Biomarkers of Idiopathic Parkinson's Disease and Parkinsonism From Exhaled Breath Using a Nanomedical Artificial Olfactory System.

Resource links provided by NLM:


Further study details as provided by Ilana Schlesinger, Rambam Health Care Campus:

Primary Outcome Measures:
  • Nanosensory detection [ Time Frame: immediate ]
    analyze combinations of nanomaterial-based sensors (organically functionalized carbon nanotubes and gold nanoparticles)


Biospecimen Retention:   Samples Without DNA
Exhaled breath

Enrollment: 41
Study Start Date: August 2009
Study Completion Date: January 2012
Primary Completion Date: January 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Patients with parkinsonism
Patients suffering from Parkinson's disease or parkinsonism
Other: collection of exhaled breath
no intervention
Healthy controls
Patients not suffering from Parkinson's disease or any other neurological disorder
Other: collection of exhaled breath
no intervention

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   30 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Patients diagnosed with Idiopathic Parkinson's disease and Parkinsonism will be included.
Criteria

Inclusion Criteria:

  • Patients with Parkinsonism

Exclusion Criteria:

  • Severe dementia
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01246336


Sponsors and Collaborators
Rambam Health Care Campus
Technion, Israel Institute of Technology
Investigators
Principal Investigator: Ilana Schlesinger, MD Rambam Health Care Campus
  More Information

Responsible Party: Ilana Schlesinger, Ilana Schleainger, Rambam Health Care Campus, Rambam Health Care Campus
ClinicalTrials.gov Identifier: NCT01246336     History of Changes
Other Study ID Numbers: RMB09-0196
First Submitted: November 21, 2010
First Posted: November 23, 2010
Last Update Posted: October 31, 2017
Last Verified: October 2017

Keywords provided by Ilana Schlesinger, Rambam Health Care Campus:
Parkinson's disease, Parkinsonism
Biomarkers
Exhaled breath
Nanothechnology

Additional relevant MeSH terms:
Parkinson Disease
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases