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Effect of Pulmonary Rehabilitation in Lung Cancer Survivors

This study has been completed.
Royal Brompton & Harefield NHS Foundation Trust
London Cancer Alliance (North West London Cancer Network)
Information provided by (Responsible Party):
Imperial College Healthcare NHS Trust Identifier:
First received: November 22, 2010
Last updated: May 12, 2016
Last verified: May 2016
Patients who have surgery to cure lung cancer often have multiple problems at hospital discharge and later on. This includes poor exercise performance and quality of life, breathlessness, pain and tiredness. Currently there is little formal physical or psychological support for such patients. This pilot study aims to investigate whether outpatient pulmonary rehabilitation (an exercise training and education programme), started within 2 weeks of hospital discharge, can lead to improvements in exercise performance and quality of life in patients who have undergone lung cancer surgery. The study will also assess whether pulmonary rehabilitation is acceptable for patients and will analyze the safety profile. The hypothesis is that patients; discharged from hospital after undergoing lung cancer surgery, have improved exercise performance and quality of life following early outpatient pulmonary rehabilitation compared with usual care.

Condition Intervention
Lung Cancer
Pulmonary Rehabilitation
Other: Pulmonary Rehabilitation
Other: Usual post operative care

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Pilot Study of Early Outpatient Pulmonary Rehabilitation Following Thoracic Surgery for Lung Cancer

Resource links provided by NLM:

Further study details as provided by Imperial College Healthcare NHS Trust:

Primary Outcome Measures:
  • Six minute walk test to assess exercise tolerance [ Time Frame: Within 3 month of discharge from surgery ]

Secondary Outcome Measures:
  • Shoulder Range of Motion Changes [ Time Frame: Within 3 months of discharge from surgery ]
  • Bioimpedence for tissue composition [ Time Frame: Within 3 months of discharge from surgery ]
  • Quality of life measurement changes [ Time Frame: Within 3 months of discharge from surgery ]

Enrollment: 30
Study Start Date: October 2010
Study Completion Date: November 2011
Primary Completion Date: July 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Usual Care
Other: Usual post operative care
Usual post operative care for post lung lobectomy patients for 8 weeks post discharge.
Active Comparator: Pulmonary Rehabilitation
Pulmonary Rehabilitation consists of twice weekly exercise classes with an educational component.
Other: Pulmonary Rehabilitation
Twice weekly exercise classes with an education component. For 8 weeks.

Detailed Description:

The research question is to investigate

  • whether patients who have undergone curative surgical resection for lung cancer benefit from 8 weeks of early outpatient pulmonary rehabilitation (started within 2 weeks of hospital discharge).
  • to identify potential barriers to this approach

Pulmonary rehabilitation (PR) is the most effective non-pharmacological treatment for patients with chronic respiratory diseases, especially COPD. Many patients with lung cancer have co-existing smoking-related lung disorders such as COPD. To date there have been no randomised controlled trials of PR in post-resection lung cancer survivors. However there is indirect evidence that PR may be of benefit in this patient cohort. Cesario et al (2007)reported a 32% improvement in exercise capacity with in-patient PR, and Spruit et al (2009) demonstrated a 43% improvement in six minute walk distance following an 8-week in-patient PR programme. However, both studies had small numbers, and no randomised control group. Furthermore, inpatient PR is not an economically justifiable intervention in the NHS where emphasis is on self-management and ambulatory care.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • All patients undergoing lung cancer surgery with curative intent.

Exclusion Criteria:

  • Unstable cardiovascular disease Severe musculo-skeletal problems that would limit exercise training(neuromuscular disorders, severe joint arthritis of lower limbs) Severe peripheral vascular disease Unable to walk 10 metres unaided Patients unable to give informed consent Recent (within 3 months of completing treatment) or untreated pulmonary TB, Untreated/uncontrolled diabetes or epilepsy Recent or recurrent untreated spontaneous pneumothorax
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Please refer to this study by its identifier: NCT01246297

United Kingdom
Harefield Hospital
Harefield, Middlesex, United Kingdom, UB9 6JH
Imperial College Healthcare Trust
London, United Kingdom, W21NY
Sponsors and Collaborators
Imperial College Healthcare NHS Trust
Royal Brompton & Harefield NHS Foundation Trust
London Cancer Alliance (North West London Cancer Network)
Principal Investigator: Sarah Elkin, FRCP Imperial College Healthcare Trust
  More Information

Responsible Party: Imperial College Healthcare NHS Trust Identifier: NCT01246297     History of Changes
Other Study ID Numbers: JROSM0090
Study First Received: November 22, 2010
Last Updated: May 12, 2016

Additional relevant MeSH terms:
Lung Neoplasms
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Lung Diseases
Respiratory Tract Diseases processed this record on May 25, 2017