Pain and Schizophrenia

This study is currently recruiting participants. (see Contacts and Locations)
Verified June 2015 by University Hospital, Strasbourg, France
Information provided by (Responsible Party):
University Hospital, Strasbourg, France Identifier:
First received: November 17, 2010
Last updated: June 18, 2015
Last verified: June 2015
The aim of the investigators project is to explore the mechanisms of pain insensitivity in patients with schizophrenia, in order to prevent its invalidating consequences. The investigators will couple methods of experimental psychology with EEG and blood samplings, in order to distinguish the role of non-painful perception, attention, aversive effects, and pain expression, and the investigators will explore an original neurobiological hypothesis regarding the activation of opioid receptors.


Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Pain and Schizophrenia

Resource links provided by NLM:

Further study details as provided by University Hospital, Strasbourg, France:

Estimated Enrollment: 107
Study Start Date: August 2011
Estimated Study Completion Date: August 2016
Estimated Primary Completion Date: August 2016 (Final data collection date for primary outcome measure)
Patients with schizophrenia
Healthy controls (controls matched with patients on age, sex and education level)


Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
  • Primary care and day clinic in Strasbourg, Erstein and Besançon
  • Healthy controls from or near Strasbourg, Erstein or Besançon.

Inclusion Criteria:

  • Patients with schizophrenia (criteria DSM IV) or healthy controls matched with patients on age, sex and education level
  • 18-55 years old

Exclusion Criteria:

  • Past history affecting CNS
  • Intake of psychotropic drugs, except for patients
  • Metabolic disorder affecting sensory processing (diabetes)
  • Intake of benzodiazepines
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01244542

Contact: Anne GIERSCH, MD 03 88 11 64 71

Service de Psychiatrie Adulte2, Place Saint-Jacques - ZA 481, Centre Hospitalier Saint-Jacques Not yet recruiting
Besançon Cedex, France, 25030
Contact: Pierre VANDEL, MD, PhD    33 3 81 21 86 11   
Principal Investigator: Pierre VANDEL, MD, PhD         
Sub-Investigator: Emmanuel HAFFEN, MD, PhD         
Service de Psychiatrie Adulte, Secteur G11, Centre Hospitalier de Erstein, 13 route de Krafft Not yet recruiting
Erstein Cedex, France, 67152
Contact: Jea n-Philippe LANG    33 3 90 64 21 16   
Contact: Jea n-Philippe LANG, MD    33 3 90 64 21 16   
Centre d'Investigation Clinique (UF 1043), Nouvel Hôpital Civil, 1, place de l'hôpital Not yet recruiting
STRASBOURG Cedex, France, 67091
Contact: Catherine MUTTER, MD    33 3 69 55 06 18   
Contact: Catherine MUTTERBRANDT, MD    33 3 69 55 06 18   
Centre d'évaluation et de traitement de la douleur, HôpitalCivil, Hôpitaux Universitaires de Strasbourg, 1, place de l'Hôpital Recruiting
Strasbourg Cedex, France, 67 091
Contact: Eric SALVAT, MD    33 3 88 11 64 83   
Principal Investigator: Eric SALVAT, MD         
Sub-Investigator: André MULLER, MD, PhD         
Sponsors and Collaborators
University Hospital, Strasbourg, France
Study Director: Anne Giersch, MD University Hospital, Strasbourg, France
  More Information

Responsible Party: University Hospital, Strasbourg, France Identifier: NCT01244542     History of Changes
Other Study ID Numbers: 4706 
Study First Received: November 17, 2010
Last Updated: June 18, 2015
Health Authority: France: Ministry of Health

Keywords provided by University Hospital, Strasbourg, France:
DSM IV criteria
Pain insensitivity
Painful perception
Opioid receptors

Additional relevant MeSH terms:
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders processed this record on July 24, 2016