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Pain and Schizophrenia

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ClinicalTrials.gov Identifier: NCT01244542
Recruitment Status : Terminated (recruitment difficulties)
First Posted : November 19, 2010
Last Update Posted : October 5, 2017
Sponsor:
Information provided by (Responsible Party):
University Hospital, Strasbourg, France

Brief Summary:
The aim of the investigators project is to explore the mechanisms of pain insensitivity in patients with schizophrenia, in order to prevent its invalidating consequences. The investigators will couple methods of experimental psychology with EEG and blood samplings, in order to distinguish the role of non-painful perception, attention, aversive effects, and pain expression, and the investigators will explore an original neurobiological hypothesis regarding the activation of opioid receptors.

Condition or disease Intervention/treatment Phase
Pain Schizophrenia Other: unpleasant stimuli Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 83 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Health Services Research
Official Title: Pain and Schizophrenia
Actual Study Start Date : August 2011
Actual Primary Completion Date : January 2015
Actual Study Completion Date : January 2015

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Schizophrenia

Arm Intervention/treatment
Experimental: Patients with schizophrenia Other: unpleasant stimuli
Active Comparator: Healthy controls
controls matched with patients on age, sex and education level
Other: unpleasant stimuli



Primary Outcome Measures :
  1. Unpleasant stimuli [ Time Frame: during experimental session ]
    acute electrical stimulation

  2. Unpleasant stimuli [ Time Frame: during experimental session ]
    emotional pictures



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Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Patients with schizophrenia (criteria DSM IV) or healthy controls matched with patients on age, sex and education level
  • 18-55 years old

Exclusion Criteria:

  • Past history affecting CNS
  • Intake of psychotropic drugs, except for patients
  • Metabolic disorder affecting sensory processing (diabetes)
  • Intake of benzodiazepines

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01244542


Locations
France
Service de Psychiatrie Adulte2, Place Saint-Jacques - ZA 481, Centre Hospitalier Saint-Jacques
Besançon Cedex, France, 25030
Service de Psychiatrie Adulte, Secteur G11, Centre Hospitalier de Erstein, 13 route de Krafft
Erstein Cedex, France, 67152
Centre d'évaluation et de traitement de la douleur, Hôpitaux Universitaires de Strasbourg
Strasbourg Cedex, France, 67 091
Centre d'Investigation Clinique - Hôpitaux Universitares de Strasbourg
Strasbourg Cedex, France, 67091
Service de Psychiatrie - Hôpitaux Universitaires de Strasbourg
Strasbourg cedex, France, 67091
Sponsors and Collaborators
University Hospital, Strasbourg, France
Investigators
Study Director: Anne Giersch, MD University Hospital, Strasbourg, France

Responsible Party: University Hospital, Strasbourg, France
ClinicalTrials.gov Identifier: NCT01244542     History of Changes
Other Study ID Numbers: 4706
First Posted: November 19, 2010    Key Record Dates
Last Update Posted: October 5, 2017
Last Verified: September 2017

Keywords provided by University Hospital, Strasbourg, France:
Schizophrenia
DSM IV criteria
Pain insensitivity
Painful perception
Opioid receptors

Additional relevant MeSH terms:
Schizophrenia
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders