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"The Effects of Oxytocin on Patients With Borderline Personality Disorder"

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified December 2014 by Prof. Dr. Markus Heinrichs, University of Freiburg.
Recruitment status was:  Recruiting
Information provided by (Responsible Party):
Prof. Dr. Markus Heinrichs, University of Freiburg Identifier:
First received: November 17, 2010
Last updated: December 8, 2014
Last verified: December 2014

RCT. Two substudies (clinical and experimental). Main objective of the trial is to examine if oxytocin, compared to placebo shows any additional effect on the therapy achievements (outcome) of patients with borderline personality disorder, who receive an in-patient standard psychotherapy (Dialectical-behavioral-therapy, Marsha Linehan (2006)).

Secondary objectives :

Investigate if oxytocin compared to placebo enhances social trust and emotion recognition in patients with borderline personality disorder. Comparison of the effects of Oxytocin on patients with BPD and major depression.

Condition Intervention
Effects of Oxytocin on Borderline Personality Disorder.
Drug: Oxytocin

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Basic Science

Resource links provided by NLM:

Further study details as provided by Prof. Dr. Markus Heinrichs, University of Freiburg:

Primary Outcome Measures:
  • BPD Symptoms [ Time Frame: BPD Symptoms ]

Estimated Enrollment: 150
Study Start Date: January 2011
Estimated Study Completion Date: January 2016
Primary Completion Date: August 2014 (Final data collection date for primary outcome measure)
Intervention Details:
    Drug: Oxytocin

Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Gender: Both, male and female
  • Minimum Age: 18 Years
  • Maximum Age: 50 Years
  • Borderline personality disorder or major depression (clinical control group)
  • Mini Mental Status Test > 27 (capacity to consent)

Exclusion Criteria:

  • chronic or acute somatic health problems
  • Schizophrenia
  • Bipolar affective disorder
  • pregnancy
  • breast feeding
  • neurological disorder
  • allergy to antidegradants
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01243658

Contact: Nicole Ower, Psychologist 0049-761-20397743

Albert-Ludwigs-Universität-Freiburg Recruiting
Freiburg, Baden-Würtemberg, Germany, 79104
Contact: Nicole Ower, Psychologist    0049-761-20397743   
Sponsors and Collaborators
Prof. Dr. Markus Heinrichs
Study Director: Markus Heinrichs, Prof. Dr. Institut für Psychologie der Univeristät Freiburg
  More Information

Responsible Party: Prof. Dr. Markus Heinrichs, University of Freiburg Identifier: NCT01243658     History of Changes
Other Study ID Numbers: OX02
Study First Received: November 17, 2010
Last Updated: December 8, 2014

Keywords provided by Prof. Dr. Markus Heinrichs, University of Freiburg:

Additional relevant MeSH terms:
Borderline Personality Disorder
Personality Disorders
Mental Disorders
Reproductive Control Agents
Physiological Effects of Drugs processed this record on May 25, 2017