Primary Outcome Measures:
Secondary Outcome Measures:
- Establishment of PET Biomarkers as a determinate of clinical benefit [ Time Frame: estimated 4 years ]
Provide reliable validated cadre of PET imaging derived biomarkers that yield a better understanding of early clinical benefit from various therapeutic agents, efficacy during therapeutics early phase clinical trials, possible predict prognosis or other long term outcomes
Radiation: Multi-tracer PET exams
Initial scan will be done before starting the trial. The other two will be done about 25 to 32 days after the trial starts. Each of the 4 PET scans will be done with up to three of the tracers (FDG, FLT, and water) depending on the type of drug they are receiving and the tumor type. The timing of the PET scans will vary. Typically the first series of PET scans will be within a few days of each other but will be obtained within one week of each other. Similarly the follow-up series of PET scans at about 28 days will be within a few days of each other depending on scheduling issues but also within one week of each other.