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Exercise and Health Intervention for Patients With Obsessive Compulsive Disorder (OCD)

This study has been completed.
National Institute of Mental Health (NIMH)
Information provided by (Responsible Party):
Butler Hospital Identifier:
First received: November 16, 2010
Last updated: July 21, 2015
Last verified: July 2015
The purpose of this study is to test the effect of a moderate-intensity aerobic exercise intervention for Obsessive Compulsive Disorder (OCD) patients interested in reducing symptoms. The investigators expect that this project will contribute much needed knowledge about the role that aerobic exercise can play in managing the effects of OCD. If moderate-intensity aerobic exercise is efficacious in helping individuals with OCD manage obsessions and compulsions, this will establish that aerobic exercise may be a valuable adjunct to other OCD treatments such as medication and therapy.

Condition Intervention Phase
Obsessive Compulsive Disorder Behavioral: Aerobic exercise Behavioral: Health and Wellness Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Testing the Efficacy of an Exercise Intervention for Patients With OCD

Resource links provided by NLM:

Further study details as provided by Butler Hospital:

Primary Outcome Measures:
  • Yale-Brown Obsessive Compulsive Scale (Y-BOCS; OCD symptomatology) [ Time Frame: 15 months ]

Enrollment: 56
Study Start Date: November 2010
Study Completion Date: March 2015
Primary Completion Date: March 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Exercise
12-week moderate-intensity behavioral exercise intervention (AE)
Behavioral: Aerobic exercise
12-week moderate-intensity behavioral exercise intervention. Weekly sessions with an exercise physiologist who will also assign weekly exercise goals.
Active Comparator: Health and Wellness
12-week health and wellness education control (HEC)
Behavioral: Health and Wellness
12-week health and wellness education control. Weekly sessions about 12 different topics related to OCD, led by an OCD expert.


Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  1. are between 18 and 65 years of age
  2. are sedentary, i.e. have not participated in regular aerobic physical exercise for at least 90 minutes per week during the past three months
  3. currently engaged in at least 12 weeks of stable dose pharmacotherapy and/or are currently engaged in cognitive-behavioral therapy for the past 13 weeks
  4. meet Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) criteria for OCD as assessed by the Structured Clinical Interview for DSM Disorders, Patient Version (SCID-P)
  5. have Y-BOCS score greater than 16

Exclusion Criteria:

  1. DSM-IV diagnosis of substance abuse/dependence except for nicotine dependence
  2. DSM-IV diagnosis of anorexia or bulimia nervosa
  3. DSM-IV diagnosis of bipolar disorder
  4. history of psychotic disorder or current psychotic symptoms
  5. current suicidality or homicidality
  6. marked organic impairment
  7. physical or medical problems that would not allow for safe exercise participation
  8. current pregnancy or intent to become pregnant during the next 12 weeks
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01242735

United States, Rhode Island
Butler Hospital
Providence, Rhode Island, United States, 02906
Sponsors and Collaborators
Butler Hospital
National Institute of Mental Health (NIMH)
Principal Investigator: Ana M Abrantes, Ph.D. Butler Hospital
  More Information

Responsible Party: Butler Hospital Identifier: NCT01242735     History of Changes
Other Study ID Numbers: 1006-001
1R01MH086513-01A1 ( U.S. NIH Grant/Contract )
Study First Received: November 16, 2010
Last Updated: July 21, 2015

Keywords provided by Butler Hospital:
Obsessive Compulsive Disorder
Aerobic Exercise

Additional relevant MeSH terms:
Compulsive Personality Disorder
Obsessive-Compulsive Disorder
Personality Disorders
Mental Disorders
Anxiety Disorders processed this record on September 19, 2017