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The Effect of Intravenous Magnesium Sulfate on Intraocular Pressure Following Tracheal Intubation

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01241175
First Posted: November 16, 2010
Last Update Posted: November 16, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Shiraz University of Medical Sciences
  Purpose
The aim of this study is to assess the effect of preoperatively administered intra venous magnesium sulfate in attenuating pressure response to laryngoscopy and endotracheal intubation in adult patients scheduled for elective non ocular surgery

Condition Intervention Phase
Increased Intra Ocular Pressure (IOP) Drug: Magnesium Sulfate Drug: normal saline Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Masking: Double (Care Provider, Outcomes Assessor)
Primary Purpose: Prevention

Resource links provided by NLM:


Further study details as provided by Shiraz University of Medical Sciences:

Primary Outcome Measures:
  • Intra ocular pressure

Secondary Outcome Measures:
  • blood pressure,heart rate

Arms Assigned Interventions
Experimental: magnesium sulfate Drug: Magnesium Sulfate
Placebo Comparator: normal saline Drug: normal saline

  Eligibility

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Ages Eligible for Study:   18 Years to 38 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • 18 to 38 years old
  • ASA I
  • scheduled for elective ENT ambulatory surgeries under general anesthesia

Exclusion Criteria:

  • specific major hepatic, renal and cardio-vascular disease
  • known to have allergic reaction to magnesium sulphate or other drugs , -hypermagnesemia
  • hypocalcemia
  • anuria
  • heart block
  • pregnancy
  • any degree of renal insufficiency
  • digitalised patients
  • positive history of glaucoma or intra ocular hypertension
  • refused to participate
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01241175


Locations
Iran, Islamic Republic of
Shiraz University of Medical Sciences
Shiraz, Fars, Iran, Islamic Republic of
Sponsors and Collaborators
Shiraz University of Medical Sciences
Investigators
Study Director: Hilda Mahmoudi, M.D Shiraz University of Medical Sciences
  More Information

ClinicalTrials.gov Identifier: NCT01241175     History of Changes
Other Study ID Numbers: 4286
First Submitted: November 15, 2010
First Posted: November 16, 2010
Last Update Posted: November 16, 2010
Last Verified: March 2009

Keywords provided by Shiraz University of Medical Sciences:
IOP
ophthalmic anesthesia
magnesium sulfate

Additional relevant MeSH terms:
Magnesium Sulfate
Analgesics
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anesthetics
Central Nervous System Depressants
Anti-Arrhythmia Agents
Anticonvulsants
Calcium Channel Blockers
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Tocolytic Agents
Reproductive Control Agents