Age 2 to 65 years, inclusive
Uncomplicated P. falciparum malaria.
Tympanic temperature greater than or equal to 37.5 degree C or history of fever within the last 24 h.
P. calciparum asexual parasite density 10,000 200,000/microL, Inclusive.
Willingness to allow the storage of blood samples collected as part of the study.
Willingness and ability of the patient/guardians to comply with the protocol for the duration of the study.
Severe malaria: diminished consciousness, respiratory distress, severe prostration, anuria, jaundice, hemoglobinuria, repetitive vomiting, or cessation of eating and drinking.
Non-malaria etiology of febrile illness (e.g., respiratory tract infection) evident on clinical examination.
Hematocrit < 25 percent
Treatment of present symptoms with an artemisinin compound or artemisinin-based combination therapy within the previous 7 days.
Pregnancy or breastfeeding
History or allergy or known contraindication to artemisinins or piperaquine