Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

Mindfulness-based Cognitive Therapy for Individuals With Multiple Chemical Sensitivity

This study has been completed.
Information provided by (Responsible Party):
Christian Riise Hauge, The Danish Research Centre for Chemical Sensitivities Identifier:
First received: November 10, 2010
Last updated: February 17, 2014
Last verified: February 2014

The objective of this study is to evaluate the effect of mindfulness-based cognitive therapy (MBCT) on physical symptoms attributed to chemical exposures, psychological distress, illness worry, quality of life, and illness perceptions in patients suffering from multiple chemical sensitivity (MCS). Furthermore, a secondary objective is to evaluate whether a possible symptom reduction is mediated by an increased level of mindfulness.

The primary hypothesis is that the self-reported severity of MCS symptoms and the degree to which chemical exposures causes symptoms and the impact on daily life will be significantly improved in the MBCT treatment group as compared to the control group.

Condition Intervention
Multiple Chemical Sensitivity
Behavioral: Mindfulness-based Cognitive Therapy (MBCT)

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by The Danish Research Centre for Chemical Sensitivities:

Primary Outcome Measures:
  • The Quick Environmental Exposure and Sensitivity Inventory (QEESI) [ Time Frame: 8 weeks, 1 year follow up ]
    QEESI is a screening instrument for MCS.

Secondary Outcome Measures:
  • The brief illness perception questionnaire (Brief IPQ) [ Time Frame: 8 weeks, 1 year follow up ]
  • The Five Facet Mindfulness Questionnaire (FFMQ) [ Time Frame: 8 weeks, 1 year follow up ]
  • Symptom Check List 92 (SCL-92) [ Time Frame: 8 weeks, 1 year follow up ]
  • The Perceived Stress Scale (PSS-10) [ Time Frame: 8 weeks, 1 year follow up ]
  • The World Health Organization Quality of Life (WHOQOL-BREF) [ Time Frame: 8 weeks, 1 year follow-up ]
  • Rumination-reflection questionnaire (RRQ) [ Time Frame: 8 weeks, 1 year follow-up ]
  • Self compassion scale short form [ Time Frame: 8 weeks, 1 year follow up ]
  • The role work functioning index [ Time Frame: 8 weeks, 1 year follow-up ]

Estimated Enrollment: 82
Study Start Date: September 2011
Study Completion Date: May 2013
Primary Completion Date: May 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: MBCT intervention Behavioral: Mindfulness-based Cognitive Therapy (MBCT)
MBCT is partly based on the mindfulness-based stress reduction program (MBSR), developed by Jon Kabat-Zinn and colleagues, and partly on cognitive therapy for depression, the latter influence particularly expressed through the aspect of "decentering", meaning not accepting the content of thoughts as facts and not identifying with the thought. The MBCT programme in this study includes 2½ hours of training once a week for 9 weeks. In addition, participants are encouraged to practice at home for up to 45 min per day, 6 days a week during the entire course.
No Intervention: Control group


Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Fulfil Lacour's criteria for Multiple Chemical Sensitivity
  • Sign a written informed consent form

Exclusion Criteria:

  • A psychotic or bipolar disorder
  • An acute psychiatric disorder requiring other treatment
  • Suicidal ideations
  • Current alcohol or drug abuse
  • Previously engaged in a mindfulness programme
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01240395

The Danish Research Centre for Chemical Sensitivities
Ledreborg Allé 40, 2., Gentofte, Denmark, 2820
Sponsors and Collaborators
The Danish Research Centre for Chemical Sensitivities
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Christian Riise Hauge, MSc psychology, The Danish Research Centre for Chemical Sensitivities Identifier: NCT01240395     History of Changes
Other Study ID Numbers: MBCT-MCS
Study First Received: November 10, 2010
Last Updated: February 17, 2014

Keywords provided by The Danish Research Centre for Chemical Sensitivities:
Multiple chemical sensitivities
Mindfulness-based cognitive therapy

Additional relevant MeSH terms:
Multiple Chemical Sensitivity
Immune System Diseases
Environmental Illness
Disorders of Environmental Origin processed this record on May 25, 2017