Association Between VEGF-C and miRNA and Clinical Non-small Cell Lung Cancer and Esophagus Squamous Cell Carcinoma
|ClinicalTrials.gov Identifier: NCT01240369|
Recruitment Status : Unknown
Verified November 2010 by China Medical University Hospital.
Recruitment status was: Active, not recruiting
First Posted : November 15, 2010
Last Update Posted : November 15, 2010
Lung cancer and esophageal cancer remain the leading causes of cancer death worldwide. The main problem is lack of effective tool in early detection that accounts for the poor outcome of cancer. Clinically, over 80% of patients with cancer were at late stage when they were diagnosed. Therefore, it is important for us to find the biomarker that serve as the early prediction of cancer.
The investigators have published that VEGFC over-expressed in non-small cell lung cancer. VEGFC plays a critical role in regulating motility of tumor cells, promotes proliferation of lymphatic endothelial cells and enhances migration and invasion. Investigator found that VEGFC over-expressed in the serum of esophageal cancer patients. Therefore, it is worthwhile to investigate the correlation between VEGFC, clinical lung cancer and esophageal cancer.
MicroRNAs (miRNAs) are conserved, endogenous, small, and noncoding RNA molecules of 21~23 nucleotides that function as post-transcriptional gene regulators. Recent studies indicated that certain microRNAs reduced in cancer patients. Therefore it is important to investigate whether specific microRNA changed in certain kinds of cancer patients.
|Condition or disease|
|VEGFC Protein in Serum VEGFC Protein in Non Small Cell Lung Cancer VEGFC Protein in ESCC CTTN Protein in ESCC miR326 in ESCC and Non Small Cell Lung Cancer|
|Study Type :||Observational|
|Estimated Enrollment :||250 participants|
|Study Start Date :||October 2010|