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Association Between VEGF-C and miRNA and Clinical Non-small Cell Lung Cancer and Esophagus Squamous Cell Carcinoma

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified November 2010 by China Medical University Hospital.
Recruitment status was:  Active, not recruiting
ClinicalTrials.gov Identifier:
First Posted: November 15, 2010
Last Update Posted: November 15, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
China Medical University Hospital

Lung cancer and esophageal cancer remain the leading causes of cancer death worldwide. The main problem is lack of effective tool in early detection that accounts for the poor outcome of cancer. Clinically, over 80% of patients with cancer were at late stage when they were diagnosed. Therefore, it is important for us to find the biomarker that serve as the early prediction of cancer.

The investigators have published that VEGFC over-expressed in non-small cell lung cancer. VEGFC plays a critical role in regulating motility of tumor cells, promotes proliferation of lymphatic endothelial cells and enhances migration and invasion. Investigator found that VEGFC over-expressed in the serum of esophageal cancer patients. Therefore, it is worthwhile to investigate the correlation between VEGFC, clinical lung cancer and esophageal cancer.

MicroRNAs (miRNAs) are conserved, endogenous, small, and noncoding RNA molecules of 21~23 nucleotides that function as post-transcriptional gene regulators. Recent studies indicated that certain microRNAs reduced in cancer patients. Therefore it is important to investigate whether specific microRNA changed in certain kinds of cancer patients.

VEGFC Protein in Serum VEGFC Protein in Non Small Cell Lung Cancer VEGFC Protein in ESCC CTTN Protein in ESCC miR326 in ESCC and Non Small Cell Lung Cancer

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Cross-Sectional

Resource links provided by NLM:

Further study details as provided by China Medical University Hospital:

Estimated Enrollment: 250
Study Start Date: October 2010
VEGF-C low
VEGF-C high
miR-326 low
miR-326 high


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Ages Eligible for Study:   50 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
ESCC and NSCLC patients

Inclusion Criteria:

  • tumor size > 0.5 cm3

Exclusion Criteria:

  • tumor size < 0.5 cm3
  Contacts and Locations
No Contacts or Locations Provided
  More Information

Responsible Party: Jen-Liang Su, China Medical University Hospital
ClinicalTrials.gov Identifier: NCT01240369     History of Changes
Other Study ID Numbers: DMR99-IRB-206
First Submitted: November 11, 2010
First Posted: November 15, 2010
Last Update Posted: November 15, 2010
Last Verified: November 2010

Keywords provided by China Medical University Hospital:

Additional relevant MeSH terms:
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Lung Diseases
Respiratory Tract Diseases
Carcinoma, Bronchogenic
Bronchial Neoplasms