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Effects of Citrulline on Gut Functioning During Excercise

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified November 2011 by Kim van Wijck, Maastricht University Medical Center.
Recruitment status was:  Enrolling by invitation
Sponsor:
ClinicalTrials.gov Identifier:
NCT01239303
First Posted: November 11, 2010
Last Update Posted: November 8, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Top Institute Food and Nutrition
Information provided by (Responsible Party):
Kim van Wijck, Maastricht University Medical Center
  Purpose
During exercise, splanchnic perfusion is compromised, resulting in organ damage in healthy individuals. Improving the availability of NO might result increase splanchnic perfusion and prevent organ damage during exercise.

Condition Intervention
Gastrointestinal Hypoperfusion Gut Damage Dietary Supplement: Citrulline Dietary Supplement: alanine

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
Official Title: Effects of Citrulline on Gut Functioning During Excercise

Resource links provided by NLM:


Further study details as provided by Kim van Wijck, Maastricht University Medical Center:

Primary Outcome Measures:
  • GI perfusion [ Time Frame: 2 hours ]
  • gut damage [ Time Frame: 5 hours ]
  • microcirculation [ Time Frame: 5 hours ]

Secondary Outcome Measures:
  • liver damage [ Time Frame: 5 hours ]
  • kidney damage [ Time Frame: 5 hours ]
  • amino acid analysis [ Time Frame: 5 hours ]

Estimated Enrollment: 30
Study Start Date: December 2010
Estimated Study Completion Date: February 2012
Estimated Primary Completion Date: January 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: citrulline Dietary Supplement: Citrulline
single dose
Placebo Comparator: alanine Dietary Supplement: alanine
single dose

Detailed Description:

The gastrointestinal (GI) tract plays an important role in the human body. The wall of the GI system regulates digestion and absorption of nutrients and it also has a very important function as a barrier between internal and external environment. The penetration of harmful substances and microbiota of the GI lumen (external environment) to the systemic circulation (internal environment) depends on this barrier. Previous studies have shown that exercise in healthy subjects provides hypoperfusion of the splanchnic area, resulting in intestinal damage, increased small intestinal permeability and liver damage. Similar splanchnic hypoperfusion occurs in patients with compromised circulation.

During episodes of splanchnic hypoperfusion, the de novo synthesis of nitric oxide (nitric oxide, NO) from arginine is compromised. This impaired NO synthesis may play a role in the development of organ dysfunction during exercise. L-citrulline administration, a precursor of arginine and NO, may result in improved NO availability and organ perfusion, thereby preventing organ damage.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • male
  • age 18-35 years

Exclusion Criteria:

  • not healthy
  • use of medication or related products
  • alcohol misuse
  • smoking
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01239303


Locations
Netherlands
Maastricht University Medical Center
Maastricht, Limburg, Netherlands, 6202 AZ
Sponsors and Collaborators
Maastricht University Medical Center
Top Institute Food and Nutrition
  More Information

Responsible Party: Kim van Wijck, MD, PhD student, Maastricht University Medical Center
ClinicalTrials.gov Identifier: NCT01239303     History of Changes
Other Study ID Numbers: MEC10-3-064
First Submitted: November 10, 2010
First Posted: November 11, 2010
Last Update Posted: November 8, 2011
Last Verified: November 2011