Combined Nutrient Intake and Muscle Protein Synthesis
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ClinicalTrials.gov Identifier: NCT01239277 |
Recruitment Status
:
Completed
First Posted
: November 11, 2010
Last Update Posted
: September 14, 2011
|
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Aging | Other: protein Other: protein and carbohydrate Other: protein and leucine | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 48 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Double (Participant, Investigator) |
Primary Purpose: | Prevention |
Official Title: | Combined Nutrient Intake and Muscle Protein Synthesis |
Study Start Date : | January 2011 |
Actual Primary Completion Date : | July 2011 |
Actual Study Completion Date : | July 2011 |
Arm | Intervention/treatment |
---|---|
Experimental: protein (elderly) |
Other: protein
20g protein
|
Experimental: protein and carbohydrate (elderly) |
Other: protein and carbohydrate
20g protein and 20g carbohydrate
|
Experimental: protein and carbohydrate (young) |
Other: protein and carbohydrate
20g protein and 20g carbohydrate
|
Experimental: protein and leucine (elderly) |
Other: protein and leucine
20g protein, 2.5g leucine
|
- Muscle protein synthesis [ Time Frame: 6 h postprandial period ]Muscle protein synthesis will be expressed as fractional synthetic rate (FSR) by dividing the increment in enrichment in the product, i.e. protein-bound C13phe, by the enrichment of the precursor (=plasma availability).

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Ages Eligible for Study: | 70 Years to 85 Years (Senior) |
Sexes Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- males
- 70-85 years or 18-30 years
- BMI < 30
Exclusion Criteria:
- Type II diabetes
- All co morbidities interacting with mobility and muscle metabolism of the lower limbs
- Use of anticoagulants
- Patients suffering from Phenylketonuria
- Participation in any regular exercise programme

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01239277
Netherlands | |
Universiteit Maastricht, Bewegingswetenschappen | |
Maastricht, Limburg, Netherlands |
Principal Investigator: | A. de Lange | Maastricht University Medical Center |
Additional Information:
Responsible Party: | Maastricht University Medical Center |
ClinicalTrials.gov Identifier: | NCT01239277 History of Changes |
Other Study ID Numbers: |
MEC 10-3-080 |
First Posted: | November 11, 2010 Key Record Dates |
Last Update Posted: | September 14, 2011 |
Last Verified: | September 2011 |
Keywords provided by Maastricht University Medical Center:
muscle FSR protein carbohydrate leucine |