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Combined Nutrient Intake and Muscle Protein Synthesis

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ClinicalTrials.gov Identifier: NCT01239277
Recruitment Status : Completed
First Posted : November 11, 2010
Last Update Posted : September 14, 2011
Sponsor:
Information provided by (Responsible Party):
Maastricht University Medical Center

Study Description
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Brief Summary:
Dietary intervention to prevent sarcopenia in elderly people. The objective of this study is to test whether combined nutrient intake plays an important role in stimulation of the muscle protein growth in elderly people; and whether it represent effective strategies to overcome the impaired muscle protein synthesis in elderly when compared with young subjects.

Condition or disease Intervention/treatment Phase
Aging Other: protein Other: protein and carbohydrate Other: protein and leucine Not Applicable

Study Design
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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 48 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Prevention
Official Title: Combined Nutrient Intake and Muscle Protein Synthesis
Study Start Date : January 2011
Actual Primary Completion Date : July 2011
Actual Study Completion Date : July 2011
Arms and Interventions
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Arm Intervention/treatment
Experimental: protein (elderly) Other: protein
20g protein
Experimental: protein and carbohydrate (elderly) Other: protein and carbohydrate
20g protein and 20g carbohydrate
Experimental: protein and carbohydrate (young) Other: protein and carbohydrate
20g protein and 20g carbohydrate
Experimental: protein and leucine (elderly) Other: protein and leucine
20g protein, 2.5g leucine


Outcome Measures
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Primary Outcome Measures :
  1. Muscle protein synthesis [ Time Frame: 6 h postprandial period ]
    Muscle protein synthesis will be expressed as fractional synthetic rate (FSR) by dividing the increment in enrichment in the product, i.e. protein-bound C13phe, by the enrichment of the precursor (=plasma availability).


Eligibility Criteria
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Ages Eligible for Study:   70 Years to 85 Years   (Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • males
  • 70-85 years or 18-30 years
  • BMI < 30

Exclusion Criteria:

  • Type II diabetes
  • All co morbidities interacting with mobility and muscle metabolism of the lower limbs
  • Use of anticoagulants
  • Patients suffering from Phenylketonuria
  • Participation in any regular exercise programme
Contacts and Locations
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Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01239277


Locations
Netherlands
Universiteit Maastricht, Bewegingswetenschappen
Maastricht, Limburg, Netherlands
Sponsors and Collaborators
Maastricht University Medical Center
Investigators
Principal Investigator: A. de Lange Maastricht University Medical Center
More Information
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Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Additional Information:
Information about research performed by the Maastricht Muscle Metabolism group at MUMC  This link exits the ClinicalTrials.gov site

Responsible Party: Maastricht University Medical Center
ClinicalTrials.gov Identifier: NCT01239277     History of Changes
Other Study ID Numbers: MEC 10-3-080
First Posted: November 11, 2010    Key Record Dates
Last Update Posted: September 14, 2011
Last Verified: September 2011

Keywords provided by Maastricht University Medical Center:
muscle
FSR
protein
carbohydrate
leucine