Combined Nutrient Intake and Muscle Protein Synthesis
This study has been completed.
Sponsor:
Maastricht University Medical Center
Information provided by (Responsible Party):
Maastricht University Medical Center
ClinicalTrials.gov Identifier:
NCT01239277
First received: November 10, 2010
Last updated: September 13, 2011
Last verified: September 2011
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Purpose
Dietary intervention to prevent sarcopenia in elderly people. The objective of this study is to test whether combined nutrient intake plays an important role in stimulation of the muscle protein growth in elderly people; and whether it represent effective strategies to overcome the impaired muscle protein synthesis in elderly when compared with young subjects.
| Condition | Intervention |
|---|---|
|
Aging |
Other: protein Other: protein and carbohydrate Other: protein and leucine |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double Blind (Participant, Investigator) Primary Purpose: Prevention |
| Official Title: | Combined Nutrient Intake and Muscle Protein Synthesis |
Further study details as provided by Maastricht University Medical Center:
Primary Outcome Measures:
- Muscle protein synthesis [ Time Frame: 6 h postprandial period ]Muscle protein synthesis will be expressed as fractional synthetic rate (FSR) by dividing the increment in enrichment in the product, i.e. protein-bound C13phe, by the enrichment of the precursor (=plasma availability).
| Enrollment: | 48 |
| Study Start Date: | January 2011 |
| Study Completion Date: | July 2011 |
| Primary Completion Date: | July 2011 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
| Experimental: protein (elderly) |
Other: protein
20g protein
|
| Experimental: protein and carbohydrate (elderly) |
Other: protein and carbohydrate
20g protein and 20g carbohydrate
|
| Experimental: protein and carbohydrate (young) |
Other: protein and carbohydrate
20g protein and 20g carbohydrate
|
| Experimental: protein and leucine (elderly) |
Other: protein and leucine
20g protein, 2.5g leucine
|
Eligibility| Ages Eligible for Study: | 70 Years to 85 Years (Senior) |
| Sexes Eligible for Study: | Male |
| Accepts Healthy Volunteers: | Yes |
Criteria
Inclusion Criteria:
- males
- 70-85 years or 18-30 years
- BMI < 30
Exclusion Criteria:
- Type II diabetes
- All co morbidities interacting with mobility and muscle metabolism of the lower limbs
- Use of anticoagulants
- Patients suffering from Phenylketonuria
- Participation in any regular exercise programme
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01239277
Please refer to this study by its ClinicalTrials.gov identifier: NCT01239277
Locations
| Netherlands | |
| Universiteit Maastricht, Bewegingswetenschappen | |
| Maastricht, Limburg, Netherlands | |
Sponsors and Collaborators
Maastricht University Medical Center
Investigators
| Principal Investigator: | A. de Lange | Maastricht University Medical Center |
More Information
Additional Information:
| Responsible Party: | Maastricht University Medical Center |
| ClinicalTrials.gov Identifier: | NCT01239277 History of Changes |
| Other Study ID Numbers: |
MEC 10-3-080 |
| Study First Received: | November 10, 2010 |
| Last Updated: | September 13, 2011 |
Keywords provided by Maastricht University Medical Center:
|
muscle FSR protein carbohydrate leucine |
ClinicalTrials.gov processed this record on May 25, 2017