Combined Nutrient Intake and Muscle Protein Synthesis

This study has been completed.

Sponsor:

Information provided by (Responsible Party):

Maastricht University Medical Center

ClinicalTrials.gov Identifier:

NCT01239277

First received: November 10, 2010

Last updated: September 13, 2011

Last verified: September 2011

History of Changes

Purpose

Dietary intervention to prevent sarcopenia in elderly people. The objective of this study is to test whether combined nutrient intake plays an important role in stimulation of the muscle protein growth in elderly people; and whether it represent effective strategies to overcome the impaired muscle protein synthesis in elderly when compared with young subjects.

Condition	Intervention
Aging	Other: protein Other: protein and carbohydrate Other: protein and leucine


Study Type:	Interventional
Study Design:	Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double Blind (Participant, Investigator) Primary Purpose: Prevention
Official Title:	Combined Nutrient Intake and Muscle Protein Synthesis

Further study details as provided by Maastricht University Medical Center:

Primary Outcome Measures:

Muscle protein synthesis [ Time Frame: 6 h postprandial period ]
Muscle protein synthesis will be expressed as fractional synthetic rate (FSR) by dividing the increment in enrichment in the product, i.e. protein-bound C13phe, by the enrichment of the precursor (=plasma availability).


Enrollment:	48
Study Start Date:	January 2011
Study Completion Date:	July 2011
Primary Completion Date:	July 2011 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
Experimental: protein (elderly)	Other: protein 20g protein
Experimental: protein and carbohydrate (elderly)	Other: protein and carbohydrate 20g protein and 20g carbohydrate
Experimental: protein and carbohydrate (young)	Other: protein and carbohydrate 20g protein and 20g carbohydrate
Experimental: protein and leucine (elderly)	Other: protein and leucine 20g protein, 2.5g leucine

Eligibility


Ages Eligible for Study:	70 Years to 85 Years (Senior)
Sexes Eligible for Study:	Male
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

males
70-85 years or 18-30 years
BMI < 30

Exclusion Criteria:

Type II diabetes
All co morbidities interacting with mobility and muscle metabolism of the lower limbs
Use of anticoagulants
Patients suffering from Phenylketonuria
Participation in any regular exercise programme

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01239277

Locations


Netherlands
Universiteit Maastricht, Bewegingswetenschappen
Maastricht, Limburg, Netherlands

Sponsors and Collaborators

Maastricht University Medical Center

Investigators


Principal Investigator:	A. de Lange	Maastricht University Medical Center

More Information

Additional Information:

Information about research performed by the Maastricht Muscle Metabolism group at MUMC This link exits the ClinicalTrials.gov site


Responsible Party:	Maastricht University Medical Center
ClinicalTrials.gov Identifier:	NCT01239277 History of Changes
Other Study ID Numbers:	MEC 10-3-080
Study First Received:	November 10, 2010
Last Updated:	September 13, 2011

Keywords provided by Maastricht University Medical Center:


muscle FSR protein carbohydrate leucine

ClinicalTrials.gov processed this record on July 19, 2017

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