We are updating the design of this site. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Combined Nutrient Intake and Muscle Protein Synthesis

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01239277
First Posted: November 11, 2010
Last Update Posted: September 14, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Maastricht University Medical Center
  Purpose
Dietary intervention to prevent sarcopenia in elderly people. The objective of this study is to test whether combined nutrient intake plays an important role in stimulation of the muscle protein growth in elderly people; and whether it represent effective strategies to overcome the impaired muscle protein synthesis in elderly when compared with young subjects.

Condition Intervention
Aging Other: protein Other: protein and carbohydrate Other: protein and leucine

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Prevention
Official Title: Combined Nutrient Intake and Muscle Protein Synthesis

Further study details as provided by Maastricht University Medical Center:

Primary Outcome Measures:
  • Muscle protein synthesis [ Time Frame: 6 h postprandial period ]
    Muscle protein synthesis will be expressed as fractional synthetic rate (FSR) by dividing the increment in enrichment in the product, i.e. protein-bound C13phe, by the enrichment of the precursor (=plasma availability).


Enrollment: 48
Study Start Date: January 2011
Study Completion Date: July 2011
Primary Completion Date: July 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: protein (elderly) Other: protein
20g protein
Experimental: protein and carbohydrate (elderly) Other: protein and carbohydrate
20g protein and 20g carbohydrate
Experimental: protein and carbohydrate (young) Other: protein and carbohydrate
20g protein and 20g carbohydrate
Experimental: protein and leucine (elderly) Other: protein and leucine
20g protein, 2.5g leucine

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   70 Years to 85 Years   (Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • males
  • 70-85 years or 18-30 years
  • BMI < 30

Exclusion Criteria:

  • Type II diabetes
  • All co morbidities interacting with mobility and muscle metabolism of the lower limbs
  • Use of anticoagulants
  • Patients suffering from Phenylketonuria
  • Participation in any regular exercise programme
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01239277


Locations
Netherlands
Universiteit Maastricht, Bewegingswetenschappen
Maastricht, Limburg, Netherlands
Sponsors and Collaborators
Maastricht University Medical Center
Investigators
Principal Investigator: A. de Lange Maastricht University Medical Center
  More Information

Additional Information:
Responsible Party: Maastricht University Medical Center
ClinicalTrials.gov Identifier: NCT01239277     History of Changes
Other Study ID Numbers: MEC 10-3-080
First Submitted: November 10, 2010
First Posted: November 11, 2010
Last Update Posted: September 14, 2011
Last Verified: September 2011

Keywords provided by Maastricht University Medical Center:
muscle
FSR
protein
carbohydrate
leucine