Is the Exhaled Nitric Oxide in Infants a Predictive Marker of Asthma ? (NOnourisson)

This study has been completed.

Sponsor:

Information provided by (Responsible Party):

Assistance Publique - Hôpitaux de Paris

ClinicalTrials.gov Identifier:

NCT01239199

First received: October 21, 2010

Last updated: February 26, 2014

Last verified: February 2014

History of Changes

Purpose

Background:

It seems that in the infants and the young children, the increase of the Exhaled Nitric Oxide (eNO) is in connection with: (1) the risk of developing respiratory symptoms; (2) the risk of family and personal atopy; (3) the intensity of the respiratory symptoms; (4) the risk of passage of recurrent wheezing to asthma; (5) and contrary to the fact that the investigators noticed at the child's a positive relation with the environmental tobacco smoke

Objective: the investigators objective is to bring to light that the rise of the eNO, a non invasive biomarker of the bronchial inflammation, would be a risk factor expected from passage of recurrent wheezing of the infant and the young child (of less than 36 months old) towards the asthma of the child.Methods: Once the diagnosis of recurrent wheezing established, the investigators estimate by questionnaire the severity of the asthma, the personal and familial atopy, the collection of the environmental data. After allergic exploration (skin tests and assay of serum total and specific IgE, complete blood count), the eNO is measured by an off-line tidal breathing method using a chemiluminescence NO analyzer. Annually, a questionnaire will be send to families to appreciate the persistence or the remission of the asthma. After a simple descriptive analysis of the population and a multifactorial descriptive analysis, the investigators shall look for the connections between the rise of the eNO and the various clinical, biological and environmental parameters known to influence the variations of this marker. Then the investigators shall select a set of explanatory variables for a multivariate analysis by a logistic regression step by step.

Condition	Intervention
Asthma	Other: Measure of the exhaled NO


Study Type:	Interventional
Study Design:	Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Diagnostic
Official Title:	Is the Exhaled Nitric Oxide in Infants a Predictive Marker of Asthma?

Resource links provided by NLM:

Drug Information available for: Nitric oxide

U.S. FDA Resources

Further study details as provided by Assistance Publique - Hôpitaux de Paris:

Primary Outcome Measures:

Measure of exhaled nitric oxide at the beginning of the study and incidence of asthma symptoms after 3 years of follow up [ Time Frame: 1 day ]

Secondary Outcome Measures:

Atopic status with total and specific IgE levels and skin test, complete blood count [ Time Frame: 1 day ]


Enrollment:	86
Study Start Date:	January 2010
Study Completion Date:	May 2011
Primary Completion Date:	May 2011 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
Experimental: Exhaled NO	Other: Measure of the exhaled NO The exhaled NO will be measure by chemiluminescence in current ventilation by an indirect method (off-line)

Detailed Description:

This study is a epidemiological observation study

Eligibility


Ages Eligible for Study:	6 Months to 36 Months (Child)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Infant between 6 and 36 months
More than 3 wheezing episodes
Questionary and biological assessment for recurrent wheeze
Signature of the consent by 2 parents or by the only one of 2 parents (if this last one is the only present in the inclusion of the child)

Exclusion Criteria:

Infant with respiratory disease in neonatal period
Infant with other obstructive pathology (cystic fibrosis, Primary Ciliary Dyskinesia,…)
Infant who have a respiratory infection less than 4 weeks
Infant with asthma exacerbation or who still have corticosteroid treatment
Infant without social security from their parents

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01239199

Locations


France
Service of multidisciplinary paediatrics (Armand-Trousseau Hospital)
Paris, Ile de France, France, 75012

Sponsors and Collaborators

Assistance Publique - Hôpitaux de Paris

Investigators


Principal Investigator:	Jocelyne Just	Trousseau Hospital - APHP

More Information

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Responsible Party:	Assistance Publique - Hôpitaux de Paris
ClinicalTrials.gov Identifier:	NCT01239199 History of Changes
Other Study ID Numbers:	P 070802
Study First Received:	October 21, 2010
Last Updated:	February 26, 2014

Keywords provided by Assistance Publique - Hôpitaux de Paris:


Infants Exhaled Nitric Oxide Asthma Tobacco smoke exposure environment

Additional relevant MeSH terms:


Asthma Bronchial Diseases Respiratory Tract Diseases Lung Diseases, Obstructive Lung Diseases Respiratory Hypersensitivity Hypersensitivity, Immediate Hypersensitivity Immune System Diseases Nitric Oxide Bronchodilator Agents Autonomic Agents	Peripheral Nervous System Agents Physiological Effects of Drugs Anti-Asthmatic Agents Respiratory System Agents Free Radical Scavengers Antioxidants Molecular Mechanisms of Pharmacological Action Neurotransmitter Agents Endothelium-Dependent Relaxing Factors Vasodilator Agents Gasotransmitters Protective Agents

ClinicalTrials.gov processed this record on June 28, 2017

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