Persistent Pulmonary Artery Hypertension After Valve Replacement (SALT)
|ClinicalTrials.gov Identifier: NCT01238731|
Recruitment Status : Unknown
Verified November 2010 by University Hospital, Bonn.
Recruitment status was: Not yet recruiting
First Posted : November 11, 2010
Last Update Posted : November 11, 2010
Background: Persistent severe pulmonary hypertension (PH) after mechanical valve replacement is a frequent finding in patients with severe valve-diseases. The reasons to develop PH are multifactorial and the prevalence of severe PH significantly worsens the patients´ outcome.
Aims: (i) To define the prevalence of PH in patients after valve replacement and (ii) to identify factors predicting persistent PH.
Methods: All patients which underwent valve replacement at our institution between the years 2008 -2010 will be screened retrospectively. Those patients with pre- procedural proven PH by means of right-heart catheterization will receive prospective follow-up with echocardiography. Diagnosis of persistent PH will be confirmed with right heart catheterization.
|Condition or disease|
|Persistent Severe PH After Valve Therapy|
|Study Type :||Observational|
|Estimated Enrollment :||300 participants|
|Official Title:||Persistence of Severe Pulmonary Artery Hypertension in Patients After vaLve replacemenT|
|Study Start Date :||January 2011|
|Estimated Primary Completion Date :||January 2011|
|Estimated Study Completion Date :||March 2012|
Patients undergoing valve replacement for severe valve disease will be screened for study entry
- Persistence of pulmonary hypertension after valve replacement for treatment of severe valve disease [ Time Frame: > 6 months after valve therapy ]
- MACCE, all cause mortality during FU [ Time Frame: Within 24 months after valve therapy ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01238731
|Contact: Christoph Hammerstingl, MDemail@example.com|
|Contact: Dirk Skowasch, MD, PhDfirstname.lastname@example.org|
|Medizinische Klinik II, University of Bonn||Not yet recruiting|
|Bonn, Germany, 53125|
|Contact: Robert Schueler, MD +4922815507 email@example.com|
|Sub-Investigator: Stefan Pabst, MD|