The Role of Respiratory Viruses in Exacerbations of Cystic Fibrosis in Adults
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|ClinicalTrials.gov Identifier: NCT01238081|
Recruitment Status : Completed
First Posted : November 10, 2010
Last Update Posted : June 1, 2012
Respiratory viruses, such as those that cause colds and influenza, are very common in the general population. The average adult will experience between 2 and 4 viral respiratory illnesses each year. It is known that respiratory viruses can cause flare-ups of chronic lung diseases such as asthma and chronic obstructive pulmonary disease. In children with CF, respiratory viral infections have been identified in nearly half of all exacerbations and are associated with a decline in lung function and increased frequency of hospital admission and acquisition of new bacterial pathogens.
Currently, little is known about the impact of viral infections on the course of CF lung disease in adults and no large-scale prospective studies in this area have been performed to date. It is unknown how often respiratory viruses can be found in patients with CF when they are well and what consequences they have on the course of exacerbations of CF lung disease. This study will identify the frequency of common viral infections in adults with CF and determine the effects they have on lung function, the rate and diversity of bacterial infection and patients' treatment burden. The information gained from this study will lead to improved prevention and treatment of respiratory infections in CF.
|Condition or disease|
Show Detailed Description
|Study Type :||Observational|
|Actual Enrollment :||100 participants|
|Official Title:||The Role of Respiratory Viruses in Exacerbations of Cystic Fibrosis in Adults.|
|Study Start Date :||December 2010|
|Actual Primary Completion Date :||April 2012|
|Actual Study Completion Date :||April 2012|
- Identification of respiratory viruses in sputum, nose- or throat-swabs [ Time Frame: 12 months ]A panel of 6 viruses will be tested for using polymerase chain reaction (PCR)technology: adenovirus, rhinovirus, metapneumovirus, parainfluenza virus 1-3, influenza A,B&C and respiratory syncytial virus
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01238081
|University Hospital of South Manchester NHS Foundation Trust|
|Manchester, Lancashire, United Kingdom, M23 9LT|
|Principal Investigator:||William G Flight, MBChB||University Hospital of South Manchester NHS FoundationTrust|