Multicentre Prospective Cohort Study of Patients With Chronic Alcoholic and/or Metabolic Liver Disease (CALMET)

Primary Outcome Measures:

• Death [ Time Frame: up to 36 months ]
  

Secondary Outcome Measures:

• Complications of liver disease [ Time Frame: up to 36 months ]
  ascites, encephalopathy, liver cancer, bleeding from oesophageal varices
  
  
• Complications of obesity [ Time Frame: up to 36 months ]
  cardiovascular diseases, pulmonary diseases, etc.
  
  
• Complications of diabetes [ Time Frame: up to 36 months ]
  renal failure,etc.
  
  

In 2010, the two most frequent chronic liver diseases are alcoholic and metabolic disease. The natural history of these two diseases is not well known. Indeed, most of the studies were retrospective and evaluated alcoholic disease or metabolic disease but never both diseases. However, these two diseases have the same histological lesions and can be associated. The knowledge of the natural history of these diseases could improve the management of patients in order to decrease complications and improve survival. The aim of this prospective study is to describe the natural history of chronic liver disease due to alcohol and/or metabolic syndrome and to identify factors associated with complications (ascites, encephalopathy, death, complications of obesity, diabetes or chronic alcohol abuse). All patients will be followed every 6 months for 3 years with clinical, biological and morphological parameters.