7T MRS in Parkinson's Disease
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|ClinicalTrials.gov Identifier: NCT01237210|
Recruitment Status : Completed
First Posted : November 9, 2010
Last Update Posted : November 1, 2019
This study is looking for healthy controls and patients with Parkinson's (PD) to perform an MR scan.
- The neurochemical profile of the SN of patients with PD as measured by high field MRS will differ from that of healthy controls, in that glutathione will be lower due to oxidative stress, lactate will be higher due to mitochondrial dysfunction, the gliosis markers myo-inositol and glutamine will be higher due to inflammation (glial activation) and N-acetylaspartate and glutamate will be lower due to neuronal loss/damage.
- There will be a relationship between neurochemical changes and disease severity.
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||78 participants|
|Official Title:||Magnetic Resonance Spectroscopy of Parkinson's Disease at 7 Tesla|
|Actual Study Start Date :||February 2010|
|Actual Primary Completion Date :||February 2019|
|Actual Study Completion Date :||February 2019|
- Magnetic resonance spectroscopy (MRS) [ Time Frame: Baseline ]We will utilize optimized magnetic resonance spectroscopy (MRS) methodology to address theories of pathogenesis of Parkinson's disease (PD) by quantifying glutathione (GSH), lactate, glutamine and myo-inositol levels of the unilateral substantia nigra (SN) of healthy volunteers and patients with PD.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01237210
|United States, Minnesota|
|University of Minnesota/CMRR|
|Minneapolis, Minnesota, United States, 55414|
|Principal Investigator:||Paul Tuite, MD||University of Minnesota|