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Bronchoalveolar Immune Response Determination (BIRD)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2011 by Bossink, A.W.J..
Recruitment status was  Not yet recruiting
Information provided by:
Bossink, A.W.J. Identifier:
First received: November 7, 2010
Last updated: June 14, 2011
Last verified: June 2011
The purpose of this study is to establish if cells present in lung tissue during extrinsic allergic alveolitis (EAA) are able to elicit an immune response against specific antigens. The hypothesis is: cells in BAL lavage fluid from patients with EAA will be responsive to specific antigens and this response can be measured using ELISPOT.

Extrinsic Allergic Alveolitis

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Study to Determine the Immune Response From Broncho-alveolar Cells Against Pigeon Specific Antigens

Resource links provided by NLM:

Further study details as provided by Bossink, A.W.J.:

Primary Outcome Measures:
  • ELISPOT response in cells obtained from broncho-alveolar lavage [ Time Frame: 2 days ] [ Designated as safety issue: No ]
    All elispots will be performed the same day, the end point will be available the next day

Secondary Outcome Measures:
  • Elispot response in cells from blood [ Time Frame: 2 days ] [ Designated as safety issue: No ]
    ELispots will be performed the same day as blood collection, results will be available the next day

Biospecimen Retention:   Samples Without DNA
Cells obtained from Broncho alveolar lavage and blood collection

Estimated Enrollment: 25
Study Start Date: September 2011
Estimated Study Completion Date: December 2012
Estimated Primary Completion Date: September 2012 (Final data collection date for primary outcome measure)
non-EAA, pigeon
subject with BAL because of diseases not suspected to be EAA
EAA, pigeon
Bird fanciers with a typical clinical presentation suspected for pigeon induced EAA

Detailed Description:
Subjects suffering from extrinsic allergic alveolitis caused by pigeons will undergo a broncho alveolar lavage. Cells obtained from this BAL will be used for ELISPOT technique with pigeon specific antigens

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients suspected to have pigeon induced extrinsic allergic alveolitis will be recruited by advertisment in bird fanciers journals. Controls will be patients at the department of pulmonology and tuberculosis needing examination for other reasons

Inclusion Criteria:

  • suspicion of pigeon induced extrinsic alveolitis

Exclusion Criteria:

  • use of oral steroids
  • unable to give informed consent
  • age below 18
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01237145

Contact: Aik Bossink, MD PhD +31 6 16092662
Contact: Melanie Dubbers, MD

Diakonessenhuis Utrecht Not yet recruiting
Utrecht, Netherlands, 3582 KE
Contact: Aik Bossink, MD PhD    +31 6 16092662   
Principal Investigator: Aik Bossink, MD PhD         
Sub-Investigator: Melanie Dubbers, MD         
Sponsors and Collaborators
Bossink, A.W.J.
Principal Investigator: Aik Bossink, MD PhD Diakonessenhuis, Utrecht
  More Information

Responsible Party: Bossink A.W.J., Diakonessenhuis Identifier: NCT01237145     History of Changes
Other Study ID Numbers: BIRD01 
Study First Received: November 7, 2010
Last Updated: June 14, 2011
Health Authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Keywords provided by Bossink, A.W.J.:
bird fancier
extrinsic allergic alveolitis
broncho-alveolar lavage

Additional relevant MeSH terms:
Alveolitis, Extrinsic Allergic
Lung Diseases, Interstitial
Lung Diseases
Respiratory Tract Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Immune System Diseases processed this record on October 21, 2016