Bronchoalveolar Immune Response Determination (BIRD)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01237145
Recruitment Status : Completed
First Posted : November 9, 2010
Last Update Posted : January 19, 2018
Information provided by (Responsible Party):
A.W.J.Bossink, Bossink, A.W.J.

Brief Summary:
The purpose of this study is to establish if cells present in lung tissue during extrinsic allergic alveolitis (EAA) are able to elicit an immune response against specific antigens. The hypothesis is: cells in BAL lavage fluid from patients with EAA will be responsive to specific antigens and this response can be measured using ELISPOT.

Condition or disease
Extrinsic Allergic Alveolitis

Detailed Description:
Subjects suffering from extrinsic allergic alveolitis caused by pigeons will undergo a broncho alveolar lavage. Cells obtained from this BAL will be used for ELISPOT technique with pigeon specific antigens

Study Type : Observational
Actual Enrollment : 10 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Study to Determine the Immune Response From Broncho-alveolar Cells Against Pigeon Specific Antigens
Study Start Date : September 2011
Actual Primary Completion Date : September 2012
Actual Study Completion Date : December 2012

Resource links provided by the National Library of Medicine

U.S. FDA Resources

non-EAA, pigeon
subject with BAL because of diseases not suspected to be EAA
EAA, pigeon
Bird fanciers with a typical clinical presentation suspected for pigeon induced EAA

Primary Outcome Measures :
  1. ELISPOT response in cells obtained from broncho-alveolar lavage [ Time Frame: 2 days ]
    All elispots will be performed the same day, the end point will be available the next day

Secondary Outcome Measures :
  1. Elispot response in cells from blood [ Time Frame: 2 days ]
    ELispots will be performed the same day as blood collection, results will be available the next day

Biospecimen Retention:   Samples Without DNA
Cells obtained from Broncho alveolar lavage and blood collection

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients suspected to have pigeon induced extrinsic allergic alveolitis will be recruited by advertisment in bird fanciers journals. Controls will be patients at the department of pulmonology and tuberculosis needing examination for other reasons

Inclusion Criteria:

  • suspicion of pigeon induced extrinsic alveolitis

Exclusion Criteria:

  • use of oral steroids
  • unable to give informed consent
  • age below 18

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01237145

Diakonessenhuis Utrecht
Utrecht, Netherlands, 3582 KE
Sponsors and Collaborators
Bossink, A.W.J.
Principal Investigator: Aik Bossink, MD PhD Diakonessenhuis, Utrecht

Responsible Party: A.W.J.Bossink, Dr, Bossink, A.W.J. Identifier: NCT01237145     History of Changes
Other Study ID Numbers: BIRD01
First Posted: November 9, 2010    Key Record Dates
Last Update Posted: January 19, 2018
Last Verified: January 2018

Keywords provided by A.W.J.Bossink, Bossink, A.W.J.:
bird fancier
extrinsic allergic alveolitis
broncho-alveolar lavage

Additional relevant MeSH terms:
Alveolitis, Extrinsic Allergic
Lung Diseases, Interstitial
Lung Diseases
Respiratory Tract Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Immune System Diseases