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Indirect Comparison Between Eltrombopag & Romiplostim

This study has been completed.
Information provided by:
GlaxoSmithKline Identifier:
First received: November 4, 2010
Last updated: November 3, 2011
Last verified: November 2011
An indirect comparison to compare the efficacy of eltrombopag versus romiplostim

Condition Intervention
Drug: Eltrombopag
Drug: Romiplostim
Drug: Placebo

Study Type: Observational
Study Design: Time Perspective: Retrospective
Official Title: Indirect Comparison of Efficacy of Treatments for Idiopathic Immune Thrombocytopenic Purpura - Review of Platelet Responses and Bleeding Events

Resource links provided by NLM:

Further study details as provided by GlaxoSmithKline:

Primary Outcome Measures:
  • Durable response: platelet count of >=50 and <400 Gi/L [ Time Frame: 6 months ]
  • Overall response: either a durable response or a transient platelet response [ Time Frame: 6 months ]

Enrollment: 1
Study Start Date: August 2009
Study Completion Date: October 2009
Primary Completion Date: October 2009 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Eltrombopag & standard of care Drug: Eltrombopag
Eltrombopag & standard of care
Romiplostim & standard of care Drug: Romiplostim
Romiplostim & standard of care
Standard of care Drug: Placebo
Placebo & standard of care

Detailed Description:
An indirect analysis was conducted to evaluate the relative efficacy of eltrombopag and romiplostim using placebo as a common comparator

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Identified through a systematic review: TRA102537, Kuter 2008

Inclusion Criteria:

  • Adults with ITP
  • Pre-specified treatment
  • Prospective clinical studies with at least 10 patients

Exclusion Criteria:

  • Adults with ITP for other reasons
  Contacts and Locations
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Please refer to this study by its identifier: NCT01236014

Sponsors and Collaborators
Study Director: GSK Clinical Trials GlaxoSmithKline
  More Information

Responsible Party: Cheri Hudson; Clinical Disclosure Advisor, GSK Clinical Disclosure Identifier: NCT01236014     History of Changes
Other Study ID Numbers: 114014
Study First Received: November 4, 2010
Last Updated: November 3, 2011

Additional relevant MeSH terms:
Blood Platelet Disorders
Hematologic Diseases processed this record on April 25, 2017