Development of New MRI Pulse Sequences for Probing Lung Function in Volunteers With Hyperpolarised 3He Gas

The recruitment status of this study is unknown because the information has not been verified recently.
Verified December 2013 by Sheffield Teaching Hospitals NHS Foundation Trust.
Recruitment status was  Recruiting
University of Sheffield
Information provided by:
Sheffield Teaching Hospitals NHS Foundation Trust Identifier:
First received: November 4, 2010
Last updated: December 3, 2013
Last verified: December 2013
To develop techniques with MRI of Helium-3 gas to give functional images of the lungs. The goal is to test a single breath-hold functional 3-He MRI pulse sequence with sensitivity to multiple functional aspects of the luncg physiology. A group of 20 healthy volunteers willbe recruited from the local research group and the results compared with existing methods that require seperate breath-holds of 3He gas

Condition Intervention Phase
Healthy Volunteers
Other: polarised 3 helium
Phase 1

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Official Title: Development of New MRI Pulse Sequences for Probing Lung Function in Volunteers With Hyperpolarised 3He Gas

Further study details as provided by Sheffield Teaching Hospitals NHS Foundation Trust:

Estimated Enrollment: 20
Study Start Date: July 2010
Arms Assigned Interventions
Experimental: polarised 3 helium
inhaled gas
Other: polarised 3 helium
1 inhalation (= 1 litre)


Ages Eligible for Study:   18 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • age 18 -70

Exclusion Criteria:

  • contraindication to MRI
  • Resting oxygen saturation <95%
  • Volunteers requiring bronchodilators less than 4 hourly
  • additional respiratory diagnoses
  • pregnancy
  Contacts and Locations
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Please refer to this study by its identifier: NCT01235494

United Kingdom
Academic Unit of Radiology, Univeristy of Sheffield Recruiting
Sheffield, South Yorkshire, United Kingdom, S10 2SJ
Contact: Jim Wild, Professor    0114 2265393   
Principal Investigator: Paul Grififths, Professor         
Sponsors and Collaborators
Sheffield Teaching Hospitals NHS Foundation Trust
University of Sheffield
  More Information

No publications provided

Responsible Party: Prof Paul Griffiths, Univeristy of Sheffield Identifier: NCT01235494     History of Changes
Other Study ID Numbers: STH15080 
Study First Received: November 4, 2010
Last Updated: December 3, 2013
Health Authority: United Kingdom: Medicines and Healthcare Products Regulatory Agency processed this record on February 11, 2016