Emergence Agitation Between Sevoflurane and Desflurane in Pediatric
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ClinicalTrials.gov Identifier: NCT01235143 |
Recruitment Status :
Completed
First Posted : November 5, 2010
Last Update Posted : October 9, 2013
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Children Urologic Diseases Ambulation Difficulty | Drug: Desflurane Drug: Sevoflurane | Not Applicable |

Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 136 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Triple (Participant, Investigator, Outcomes Assessor) |
Primary Purpose: | Prevention |
Official Title: | Comparison the Incidence of Emergence Agitation Between Sevoflurane and Desflurane After Pediatric Urologic Surgery |
Study Start Date : | May 2010 |
Actual Primary Completion Date : | August 2012 |
Actual Study Completion Date : | August 2012 |

Arm | Intervention/treatment |
---|---|
Experimental: desflurane anesthesia
maintenance anesthesia with desflurane
|
Drug: Desflurane
Desflurane (not more than 1 MAC) for maintenance of anesthesia in urologic surgery
Other Name: Suprane (desflurane, USP) |
Active Comparator: sevoflurane
maintenance anesthesia with sevoflurane
|
Drug: Sevoflurane
Sevoflurane (not more than 1 MAC) for maintenance of anesthesia in urologic surgery
Other Name: sevorane |
- the incidence of emergence agitation [ Time Frame: average recovery room period was 120 minutes ]to compare the incidence of emergence agitation between sevoflurane anesthesia and desflurane anesthesia in pediatric ambulatory urologic surgery.
- the recovery profile [ Time Frame: average recovery room period was 120 minutes ]to compare the recovery profile such as awakening time. Duration of PACU stay, and also intraopertive and PACU respiratory adverse events between sevoflurane anesthesia and desflurane anesthesia.

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Ages Eligible for Study: | 1 Year to 9 Years (Child) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- children aged 1-9 years, with American Society of Anesthesiologists (ASA) physical status I or II ,
- scheduled to undergo elective ambulatory urologic surgery under general anesthesia combined with regional block
Exclusion Criteria:
- emergency procedures
- medical contraindication to placement of a caudal block
- mental retardation
- developmental delay
- attention-deficit/hyperactivity disorder
- psychiatric illness
- a history of paradoxical excitation with sedatives

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01235143
Thailand | |
Songklanagarind Hospital | |
Hat yai, Songkhla, Thailand, 90110 |
Principal Investigator: | Maliwan Oofuvong, MD | Prince of Songkla University |
Responsible Party: | maliwan oofuvong, Assistant Professor, Prince of Songkla University |
ClinicalTrials.gov Identifier: | NCT01235143 |
Other Study ID Numbers: |
PSU 136 |
First Posted: | November 5, 2010 Key Record Dates |
Last Update Posted: | October 9, 2013 |
Last Verified: | October 2013 |
incidence emergence agitation sevoflurane desflurane ambulatory pediatric surgery |
Psychomotor Agitation Emergence Delirium Urologic Diseases Mobility Limitation Dyskinesias Neurologic Manifestations Nervous System Diseases Psychomotor Disorders Neurobehavioral Manifestations Delirium Confusion Postoperative Complications |
Pathologic Processes Neurocognitive Disorders Mental Disorders Sevoflurane Desflurane Platelet Aggregation Inhibitors Anesthetics, Inhalation Anesthetics, General Anesthetics Central Nervous System Depressants Physiological Effects of Drugs |