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Effects of Aerobic Training in End Stage Renal Disease Patients
This study has been completed.
Sponsor:
Federal University of Juiz de Fora
Information provided by:
Federal University of Juiz de Fora
ClinicalTrials.gov Identifier:
NCT01234688
First received: November 3, 2010
Last updated: NA
Last verified: July 2010
History: No changes posted
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Purpose
The investigators raised the hypothesis that exercise training would be associated with improvement in exercise tolerance and VO2 kinetics in hemodialysis patients.
| Condition | Intervention |
|---|---|
| Kidney Failure, Chronic | Other: Exercise training |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Treatment |
| Official Title: | Effects of Aerobic Training During Hemodialysis on Exercise Tolerance in End Stage Renal Disease Patients |
Resource links provided by NLM:
Further study details as provided by Federal University of Juiz de Fora:
Primary Outcome Measures:
- Effects of aerobic training during hemodialysis on exercise tolerance and VO2 kinetics in end stage renal disease patients [ Time Frame: 3 months ]Before and after the intervention or control periods, the participants were submitted to an incremental work rate test and, two days apart, to a constant work rate test to the limit of tolerance.
| Enrollment: | 28 |
| Study Start Date: | June 2008 |
| Study Completion Date: | June 2010 |
| Primary Completion Date: | June 2010 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: Exercise training
Patients included in the exercise group were submitted to intra-dialytic exercise training, 3 times per week for 12 weeks.
|
Other: Exercise training
Patients included in the exercise group were submitted to intra-dialytic exercise training, 3 times per week for 12 weeks.
Other Name: Exercise group
|
|
No Intervention: Control
Patients allocated to the control group remained in regular dialysis treatment during the same timeframe.
|
Detailed Description:
End-stage renal disease (ESRD) is associated with several hemodynamic and peripheral muscle abnormalities which could slow the kinetics of O2 uptake(VO2)and diminished tolerance to incremental exercise. Although previous studies have shown that aerobic training is able to accelerate VO2 kinetics in several disease populations, little is known if these positive findings are also applicable to hemodialysis patients.
Eligibility| Ages Eligible for Study: | 18 Years and older (Adult, Senior) |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | No |
Criteria
Inclusion Criteria:
The sample included end stage renal disease patients undergoing hemodialysis, three times per week totaling 12h weekly, for at least 6 months in the Nephrology Unit at the University Hospital of the Federal University of Juiz de Fora, State of Minas Gerais, Brazil. No patient had been involved in any kind of exercise training in the preceding 6 months
Exclusion Criteria:
- unstable angina;
- uncontrolled arrhythmia;
- uncompensated heart failure;
- uncontrolled hypertension (systolic blood pressure ≥ 200 mmHg and/or diastolic blood pressure ≥ 120 mmHg);
- diabetes mellitus;
- severe respiratory diseases;
- acute infection;
- severe renal osteodystrophy;
- neurological or musculoskeletal disturbances
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01234688
Please refer to this study by its ClinicalTrials.gov identifier: NCT01234688
Locations
| Brazil | |
| Federal University of Juiz de Fora-Núcleo Interdisciplinar de Estudos e Pesquisas em Nefrologia (NIEPEN) | |
| Juiz de Fora, Minas Gerais, Brazil, 36036-330 | |
Sponsors and Collaborators
Federal University of Juiz de Fora
Investigators
| Principal Investigator: | Maycon M Reboredo, DSc | Federal University of Juiz de Fora |
| Study Director: | Rogério B de Paula, DSc | Federal University of Juiz de Fora |
More Information
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
| Responsible Party: | Maycon de Moura Reboredo, DSc, Federal University of Juiz de Fora |
| ClinicalTrials.gov Identifier: | NCT01234688 History of Changes |
| Other Study ID Numbers: |
001 |
| Study First Received: | November 3, 2010 |
| Last Updated: | November 3, 2010 |
Keywords provided by Federal University of Juiz de Fora:
|
Exercise Tolerance Physical Endurance |
Additional relevant MeSH terms:
|
Kidney Diseases Kidney Failure, Chronic Renal Insufficiency Urologic Diseases Renal Insufficiency, Chronic |
ClinicalTrials.gov processed this record on June 23, 2017