Living With Aphasia: An International Study

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01234090
Recruitment Status : Terminated (Funding stopped)
First Posted : November 4, 2010
Last Update Posted : June 15, 2016
The Solomon Foundation
The University of Queensland
Information provided by (Responsible Party):
New York University School of Medicine

Brief Summary:
This prospective cohort study hypothesizes that an analysis of parallel qualitative and quantitative data is necessary to examine the full experience of living with aphasia. It is also hypothesized that there are specific factors that act as barriers or facilitators to successfully living with aphasia. A unique aspect of the project is the use of the Assessment for Living with Aphasia (ALA), a new aphasia friendly measure based on the World Health Organization International Classification of Functioning, Disability and Health (WHO ICF). Each session will assess written and spoken language, functional communication, mobility, Activities of Daily Living (ADL) function, burden of stroke, quality of life, and depression.

Condition or disease

  Show Detailed Description

Study Type : Observational
Actual Enrollment : 15 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Living With Aphasia: An International Study
Study Start Date : June 2010
Actual Primary Completion Date : May 2012
Actual Study Completion Date : May 2012

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Aphasia
U.S. FDA Resources

Persons with Aphasia

Primary Outcome Measures :
  1. The Assessment for Living with Aphasia [ Time Frame: 9 months ]
    A new, aphasia friendly measure based on the World Health Organization International Classification of Functioning, Disability, and Health. It is a specialized tool using a self-rating scale and is focused on specific themes that have emerged from previous research.

Secondary Outcome Measures :
  1. Western Aphasia Battery - Revised [ Time Frame: 9 months ]
    This measure is designed to assess clinical aspects of language functions in aphasic patients and to provide the data needed to establish a prognosis for therapy.

  2. Successfully Living with Aphasia Rating Scale [ Time Frame: 9 months ]
    This scale is a quantitative self-rating of how successfully a person is living with aphasia.

  3. Burden of Stroke Scale [ Time Frame: 9 months ]
    The Burden of Stroke Scale is a health-status assessment instrument designed to measure patient-reported difficulty in multiple domains of functioning, psychological distress associated with specific functional limitations, and general well-being in stroke survivors.

  4. Aphasia Depression Rating Scale [ Time Frame: 9 months ]
    The Aphasic Depression Rating Scale (ADRS) was developed to detect and measure depression in aphasic patients during the subacute stage of stroke.

  5. The Wepman Self-Correction Scale [ Time Frame: 9 months ]
    This scale, based on a continuum, measures disturbances in the ability of the person with aphasia to self-correct speech and language errors.

  6. The Barthel Index [ Time Frame: 9 months ]
    This measure is a simple index of independence to score the ability of a patient with a neuromuscular or musculoskeletal disorder to care for himself.

  7. The Functional Communication Profile [ Time Frame: 9 months ]
    This rating scale is for persons with aphasia which considers 45 everyday communication behaviors. Ratings of each behavior are made on a 9-point scale, based on observations of the patient during an informal conversation.

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Inpatient/outpatient hospital population

Inclusion Criteria:

  • 18 years of age and older, willingness to be videotaped, first incidence of aphasia secondary to stroke with stroke onset ≤2.5
  • months pre-stroke or 3.5 months post-stroke with no significant complicating concomitant conditions (e.g. dementia, schizophrenia),
  • premorbid fluency/literacy in English, and no history of psychiatric disorder, and sufficient communication ability (including adequate hearing and vision) in English to participate in an interview as determined by a qualified speech pathologist based on administration of the Western Aphasia Battery - Revised and clinical observation.
  • participants will be enrolled in the study at 3 months post onset (+/- 2 weeks) wherever they are living, and presence of aphasia will be confirmed at the beginning of the first interview using the Aphasia Quotient cut offs of the Western Aphasia Battery.
  • participants with severe global aphasia will only be excluded after the interview if meaningful responses cannot be obtained using all available communication support tools. Hence, participants with a range of aphasia severity will be included.

Exclusion Criteria:

  • unwillingness to be videotaped
  • onset of stroke <2.5 months post and >3.5 months post
  • moderate or severe dementia
  • symptoms of another preexisting neurological condition other than or in addition to aphasia due to stroke, or drug abuse
  • neurological surgical treatment not including a surgical treatment specifically for treatment of stroke, absence of aphasia.
  • no subjects will have a hearing loss unexpected for his/her chronological age.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01234090

United States, New York
New York University School of Medicine
New York, New York, United States, 10016
Sponsors and Collaborators
New York University School of Medicine
The Solomon Foundation
The University of Queensland
Principal Investigator: Martha T Sarno, MA,Dhonorary New York University School of Medicine

Responsible Party: New York University School of Medicine Identifier: NCT01234090     History of Changes
Other Study ID Numbers: 10-01628
First Posted: November 4, 2010    Key Record Dates
Last Update Posted: June 15, 2016
Last Verified: June 2016

Keywords provided by New York University School of Medicine:
Quality of Life

Additional relevant MeSH terms:
Speech Disorders
Language Disorders
Communication Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms