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Short Atrioventricular Delay Pacing (SAVD)

This study has been withdrawn prior to enrollment.
Information provided by (Responsible Party):
University of Pittsburgh Identifier:
First received: November 2, 2010
Last updated: January 4, 2016
Last verified: January 2016
We intend to examine the effects of temporary elevation of atrial wall stress by shortening of the atrioventricular delay in patients with dual-chamber pacemakers.

Condition Intervention
Chronically (i.e. Implanted for at Least Six Months) Dual-chamber Pacemaker Stable Cardiac Status (i.e. no Hospitalizations or Cardiac Medication Changes Within 3 Months) Other: short AVD pacing ; prior (stable) programming

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Care Provider, Investigator)
Official Title: Short Atrioventricular Delay Pacing

Further study details as provided by University of Pittsburgh:

Primary Outcome Measures:
  • serum biomarker concentrations [ Time Frame: 30 days ]

Enrollment: 0
Study Start Date: January 2011
Study Completion Date: January 2011
Primary Completion Date: January 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: short AVD pacing
short AVD pacing
Other: short AVD pacing ; prior (stable) programming
short AVD pacing prior (stable) programming
No Intervention: prior (stable) programming
prior (stable) programming


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Chronically (i.e. implanted for at least six months) dual-chamber pacemaker
  • Stable cardiac status (i.e. no hospitalizations or cardiac medication changes within 3 months)
  • Ability to provide informed consent

Exclusion Criteria:

  • Age <18 years or >80 years
  • Pregnancy (if pregnancy is suspected, a urine pregnancy test will be performed)
  • Recent (within 12 months) left ventricular ejection fraction <50%
  • Significant valvular heart disease (mitral regurgitation of greater than mild severity, any degree of mitral stenosis, aortic stenosis or insufficiency of greater than mild severity)
  • Prior coronary artery bypass graft or valve surgery, recent (i.e. within 3 months) acute coronary syndrome or percutaneous coronary intervention, or chronic stable angina
  • History of clinically important atrial or ventricular tachyarrhythmias, defined as complex ventricular ectopy (i.e. couplets, triplets, or ventricular tachycardia), AF, atrial tachycardia, or other supraventricular tachycardias not cured with prior ablative therapy).
  • Significant chronic systemic inflammatory or neoplastic disease
  • Chronic renal or hepatic insufficiency. Renal insufficiency will be defined as a creatinine clearance of less than 20 cc/min. Evidence of hepatic insufficiency will consist of abnormal synthetic function (INR >1.4 without oral anticoagulant use, albumin < 3.0 mg/dL) or abnormal clearance function (total bilirubin >2.0).
  • Uncorrected thyroid abnormalities
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Please refer to this study by its identifier: NCT01233661

United States, Pennsylvania
Atrial Arrhythmia Center, UPMC
Pittsburgh, Pennsylvania, United States, 15213
Sponsors and Collaborators
University of Pittsburgh
Principal Investigator: David S. Schwartzman, MD Universtity of Pittsburgh
  More Information

Responsible Party: University of Pittsburgh Identifier: NCT01233661     History of Changes
Other Study ID Numbers: 08060137
Study First Received: November 2, 2010
Last Updated: January 4, 2016 processed this record on September 21, 2017