Secondary Prevention of Atrial Fibrillation (Impact of Renin-Angiotensin-Aldosterone System Inhibition)
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|ClinicalTrials.gov Identifier: NCT01233635|
Recruitment Status : Terminated (inadequate enrollment rate)
First Posted : November 3, 2010
Last Update Posted : January 5, 2016
In the present application, we propose to refine and extend current insight into AAF mechanism and therapy by examining the importance of pharmacologic RAAS inhibition, ACE genotype, and their interaction in secondary AF prevention. We have 3 specific aims:
- To confirm that RAAS inhibition therapy reduces the incidence of AF recurrence.
- To test the hypothesis that the incidence of AF recurrence in the absence of RAAS inhibition therapy is higher among patients with the D allele.
- To explore the hypothesis that RAAS inhibition therapy is more effective for preventing AF recurrence in patients with the DD genotype than in those with DI or II genotypes.
|Condition or disease||Intervention/treatment||Phase|
|Atrial Fibrillation||Other: no drug Drug: start cozaar Drug: continue cozaar||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||228 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Secondary Prevention of Atrial Fibrillation (Impact of Renin-Angiotensin-Aldosterone System Inhibition)|
|Study Start Date :||November 2005|
|Actual Primary Completion Date :||November 2007|
|Actual Study Completion Date :||November 2007|
Experimental: A Group 1 no drug
Patients who have not taken ACE/ARB, randomized to no drug.
Other: no drug
none, no drug
Experimental: A Group 2
Patients who have not taken ACE/ARB, randomized to take cozaar.
Drug: start cozaar
Patients currently taking ACE/ARB will have their prescription changed to cozaar.
Drug: continue cozaar
- AF burden [ Time Frame: 1 year ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01233635
|United States, Pennsylvania|
|Pittsburgh, Pennsylvania, United States, 15213|