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Biomarkers of Bone Resorption in Metastatic Prostate Cancer

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01233557
First Posted: November 3, 2010
Last Update Posted: November 5, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
University of Aberdeen
  Purpose
Biomarkers of bone resorption will be measured in the blood of patients with bone metastases from prostate cancer during the course of their illness. Changes in these biomarkers will be correlated with the patient's treatment with antiandrogen therapy and bisphosphonates and the response and/or progression of their cancer. It is hoped that serial measurement of these biomarkers may allow therapeutic monitoring in the future with successful individualisation of bisphosphonate therapy for metastatic prostate cancer.

Condition
Metastatic Prostate Cancer

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Measurement of Biomarkers of Bone Resorption in Patients With Hormone Sensitive Bone Metastases From Prostate Cancer Treated With Antiandrogen Therapy and Bisphosphonates

Resource links provided by NLM:


Further study details as provided by University of Aberdeen:

Enrollment: 40
Study Start Date: September 2010
Study Completion Date: August 2014
Primary Completion Date: August 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts
Bone Metastases

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   40 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
men with hormone sensitive prostate cancer with bone metastases
Criteria

Inclusion Criteria:

  • prostate cancer with bone metastases
  • hormone sensitive

Exclusion Criteria:

  • inadequate renal function
  • ongoing dental problems
  • previous bisphosphonate therapy
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01233557


Locations
United Kingdom
Aberdeen Royal Infirmary
Aberdeen, United Kingdom, AB25 2ZN
Sponsors and Collaborators
University of Aberdeen
Investigators
Principal Investigator: Donald Bissett, M.D. NHS Grampian
  More Information

Responsible Party: University of Aberdeen
ClinicalTrials.gov Identifier: NCT01233557     History of Changes
Other Study ID Numbers: 10/S0802/36
First Submitted: November 2, 2010
First Posted: November 3, 2010
Last Update Posted: November 5, 2015
Last Verified: November 2015

Additional relevant MeSH terms:
Prostatic Neoplasms
Bone Resorption
Genital Neoplasms, Male
Urogenital Neoplasms
Neoplasms by Site
Neoplasms
Genital Diseases, Male
Prostatic Diseases
Bone Diseases
Musculoskeletal Diseases