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Effect of Ageing on Airway Remodeling

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ClinicalTrials.gov Identifier: NCT01230879
Recruitment Status : Terminated
First Posted : October 29, 2010
Last Update Posted : June 7, 2017
Sponsor:
Information provided by (Responsible Party):
University Hospital, Montpellier

Brief Summary:
The aim of the study is to investigate the relationship between aging and morphological changes in the lung. 120 consecutive healthy volunteers over 60 years will be enrolled for this trial.

Condition or disease Intervention/treatment Phase
Aging Other: EFR and TDM Not Applicable

Detailed Description:
Chest multidetector CT without injection and spirometry data will be obtained from a multicentric sample of individuals between 60 and 95 years of ageExclusion criteria were current smoking, history of smoking within the past 10 years, any known chronic or acute pulmonary disease. Individuals treated with Amiodarone, Bleomycin or methotrexate were excludedOutcome

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 101 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Study of Bronchoalveolar Lung Remodeling in Subjects From 60 Years Free of Progressive Lung Disease: Structure-function Analysis
Study Start Date : July 15, 2009
Actual Primary Completion Date : August 2012
Actual Study Completion Date : August 2012

Arm Intervention/treatment
Experimental: 60 - 70 years old
EFR and TDM
Other: EFR and TDM
EFR : Pulmonary function test TDM : tomodensitometry

Experimental: 71 - 80 years old
EFR and TDM
Other: EFR and TDM
EFR : Pulmonary function test TDM : tomodensitometry

Experimental: 81 - 95 years old
EFR and TDM
Other: EFR and TDM
EFR : Pulmonary function test TDM : tomodensitometry




Primary Outcome Measures :
  1. Bronchial wall thickness [ Time Frame: 1 day ]
    Bronchial wall thickness and remodeling associated with aging



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Ages Eligible for Study:   60 Years to 95 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • People from 60 to 95 years old free from chest disease or history of chest disease

Exclusion Criteria:

  • Chronic cough
  • Dyspnea
  • Sinonasal or chest infection during enrollment
  • Myocardial infarction.
  • Current smoker or past smoker with more than 10 pack year intoxication

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01230879


Locations
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France
University Montpellier Hospital
Montpellier, France, 34295
Sponsors and Collaborators
University Hospital, Montpellier
Investigators
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Principal Investigator: BOMMART Sebastien, MD University Montpellier Hospital

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: University Hospital, Montpellier
ClinicalTrials.gov Identifier: NCT01230879     History of Changes
Other Study ID Numbers: 8268
First Posted: October 29, 2010    Key Record Dates
Last Update Posted: June 7, 2017
Last Verified: April 2014

Keywords provided by University Hospital, Montpellier:
Aging lung
Airway remodeling
Airway segmentation
Chest CT

Additional relevant MeSH terms:
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Airway Remodeling
Pathological Conditions, Anatomical