We updated the design of this site on September 25th. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

The Relation Between Obesity, Adipose Tissue Content of Fatty Acids and Systemic and Airway Inflammation

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01229787
First Posted: October 28, 2010
Last Update Posted: October 28, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Merck Sharp & Dohme Corp.
Information provided by:
Cyprus International Institute for Environment and Public Health
  Purpose

Obesity has been recognized as a risk factors for developing asthma. In a cohort of 5384 children aged 15-17, we aim to:

  1. To investigate the association of asthma prevalence at age 15-17 with body mass index (BMI) at age 15-17 and BMI at age 11-12 years Part II
  2. To investigate the association of BMI in adolescence and BMI at age 11-12 years with:

    1. Prevalence of allergic sensitization
    2. Lung function
    3. Levels of airway inflammation at age 16-18 years
    4. Severity of asthma

Secondly, to assess diet and physical activity involvement as effect modifiers in these possible associations.


Condition
Asthma, Allergies and Obesity

Study Type: Observational
Study Design: Time Perspective: Cross-Sectional
Official Title: The Relation Between Obesity, Adipose Tissue Content of Fatty Acids and Systemic and Airway Inflammation

Further study details as provided by Cyprus International Institute for Environment and Public Health:

Primary Outcome Measures:
  • The association between asthma prevalence in adolescence and obsity in adolescence and in childhood
    To investigate the association of asthma prevalence at age 15-17 with body mass index (BMI) at age 15-17 and at age 11-12 years


Secondary Outcome Measures:
  • Association of BMI in adolescence and in childhood with allergic sensitization and lung function

    To investigate the association of BMI in adolescence and BMI at age 11-12 years with:

    1. Prevalence of allergic sensitization
    2. Lung function
    3. Levels of airway inflammation at age 16-18 years
    4. Severity of asthma


Enrollment: 5384
Study Start Date: January 2007
Study Completion Date: December 2009
  Show Detailed Description

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   15 Years to 17 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Part I took place in 2007 and children 15-16 and 16-17 years across Cyprus were invited to participate. The targeted population were 19849 children that participated in an earlier study in years 2001-3 and had anthropometric measurements, assessment of cardio-respiratory fitness and serum lipids taken at that time. The subjects of the second part of the study were selected from the 5384 subjects that had participated in the first part and had matched data on current and past BMI. We targeted subjects for part two of the study with the following criteria:1. Current Wheezers: All active asthmatics across all BMI subgroups. Definition of Current Wheezer: Positive answer to the question in ISAAC questionnaire: "Have you had wheezing in the past 12 months?" 2. Never Wheezers: 700 controls selected in a random way across all BMI groups. Definition of Never Wheezer: Negative answers to both of the following two questions: "Have you ever had wheezing?" and "Have you ever had asthma?"
Criteria

Inclusion Criteria:

Exclusion Criteria:

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01229787


Locations
Cyprus
Cyprus International insitute
Nicosia, Cyprus
Sponsors and Collaborators
Cyprus International Institute for Environment and Public Health
Merck Sharp & Dohme Corp.
Investigators
Principal Investigator: Panayiotis Yiallouros, MD, PhD Cyprus International Insitute
  More Information

Responsible Party: Dr Panayiotis Yiallouros, Cyprus International Institute for the Environment and Public Health
ClinicalTrials.gov Identifier: NCT01229787     History of Changes
Other Study ID Numbers: CIIRespiratory1
First Submitted: October 27, 2010
First Posted: October 28, 2010
Last Update Posted: October 28, 2010
Last Verified: July 2009

Keywords provided by Cyprus International Institute for Environment and Public Health:
asthma
allergies
obesity

Additional relevant MeSH terms:
Obesity
Inflammation
Overnutrition
Nutrition Disorders
Overweight
Body Weight
Signs and Symptoms
Pathologic Processes