Primary Outcome Measures:
- Evaluation of Ocular Surface [ Time Frame: Over the course of multiple years ] [ Designated as safety issue: No ]
Objectively evaluate the ocular surface (pre-corneal tear film) of individuals prior to and after an intervention (such as a dry eye treatment, environmental change, artificial tear use, or contact lens wear) in a controlled-environmental chamber, over time using non-contact instruments.
Other: Patient-directed or physician-recommended interventions.
These interventions may include obtaining baseline data (prior to the intervention) and data after the intervention that may be performed at one or more visits. The subject's physician may recommend performing a dry eye treatment, such as wearing moisture retaining goggles, performing lid massage, using compresses or scrubs, or taking a nutritional supplement. The subject may decide to begin a homeopathic intervention such as water misting, humidifier use or exposure to an herbal scent. The subject may perform the intervention for a period of time and then come to the research site for measurements or may perform the intervention at the study site so measurements are timed close to the intervention. The study duration is one or two visits in one day each lasting about one hour. Depending on the intervention a second visit may be requested on the same day, for example, to determine if the effects of lid massage are effective for 6-8 hours.
Other: Environmental Chamber Condition Change Intervention
For condition change studies, the chamber will operate between 65 and 85 degrees F and 25% and 80% RH with air flow turned off or set to a maximum of 3-4 m/s. For this type of study, we will have the subject acclimate to a set of environmental conditions (approximately 20-30 minutes) and take a set of measurements. Then we will change the conditions (rate of change is 3 degrees F/hour and 3% RH/hour), have the subject acclimate to these conditions (later on the same day or on another day) and take another set of measurements. The expected study length is approximately two hours for a single visit. Subjects may be asked to return for additional visits to accommodate a variety of chamber conditions (temp, humidity, airflow) within the prescribed limits above.
Drug: Eye Drop Intervention
This type of intervention will require a screening exam to confirm the subject's eye condition and suitability for study. These studies use FDA-approved over-the-counter eye drops, artificial tears or saline (dilute solution of salt water) used as indicated by the FDA. Dispensing will use a new single use container or separate bottle for each subject. We will instill one drop in the eye. The study length is one visit lasting a maximum of two hours.
Other: Contact Lens Intervention
A screening exam is required to confirm the subject's eye condition and suitability for study. We will have experienced lens wearers wear their own lenses or wear the same type of lenses (soft or rigid gas permeable [RGP]) within the FDA approved modality (daily, continuous or extended wear) and replacement cycle (for example, daily, one week, one month, etc.) as described in the lens package insert and/or prescribed by their eye care provider. We will take measurements of the subject without the lenses, have the subject insert the lenses, wait about five minutes for the eye to settle down, then take another set of measurements. The subject will then leave the site and return for a second visit at 6-8 hours of wear for an additional measurement and a final measurement five minutes after removal of the contact lenses. Each visit may take a maximum of one hour. If the subject did not wear his/her own pair of contact lenses, the subject will return the lenses.
We are interested in obtaining information about your current eye status with no or only a slight behavioral change. For example, we may ask you to blink in a certain way, such as with your normal blink rate, or with a more or less frequent blink than your normal rate. Or we may ask you to perform an everyday task, such as reading a book or watching a monitor. These tasks are considered non-invasive as they are tasks individuals might perform during the day to relieve dry eye symptoms.