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Clinical Trial Comparing Continuous Versus Intermittent Hemodialysis in ICU Patients (CONVINT)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01228123
First Posted: October 26, 2010
Last Update Posted: May 25, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Charite University, Berlin, Germany
  Purpose
The mortality of acute renal failure (ARF) remains to be high (around 60-70%) despite manifold improvements in ICU care. At present, it is not clear if the method chosen for renal replacement therapy, i.e. intermittent haemodialysis (IHD) or continuous haemofiltration (CVVH), might impact on the outcome of these patients. For this purpose, a prospective randomised clinical study of the effect of continuous versus intermittent renal replacement therapy on the mortality and outcome of acute renal failure will be performed.

Condition Intervention Phase
Acute Renal Failure Other: RRT for acute kidney failure using the CVVH method Other: RRT for acute kidney failure using the IHD (intermittent HD) Phase 2 Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Prospective Randomised Clinical Trial of the Effect of Continuous Versus Intermittent Renal Replacement Therapy on the Mortality and Outcome of Acute Renal Failure in ICU Patients

Further study details as provided by Charite University, Berlin, Germany:

Primary Outcome Measures:
  • Survival at 2 weeks after RRT [ Time Frame: 2 weeks after RRT in follow-up ]

Enrollment: 252
Study Start Date: January 2002
Study Completion Date: January 2008
Primary Completion Date: October 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: CVVH arm Other: RRT for acute kidney failure using the CVVH method
patients randomized to receive CVVH
Other Name: does not apply
Active Comparator: IHD arm Other: RRT for acute kidney failure using the IHD (intermittent HD)
patients randomized to receive IHD
Other Name: does not apply

Detailed Description:
please see above
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • all ICU patients requiring renal replacement therapy

Exclusion Criteria:

  • patient denies informed consent
  • patient not requiring intensive care therapy
  • kidney transplanted patients
  • chronic renal failure (serum creatinine > 3mg/dl)
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01228123


Locations
Germany
Charite University Medicine
Berlin, Germany, 13353
Sponsors and Collaborators
Charite University, Berlin, Germany
Investigators
Principal Investigator: Achim Joerres, MD Charite University Medicine
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: investigator initiated trial (see adress below), Charite University Medicine
ClinicalTrials.gov Identifier: NCT01228123     History of Changes
Other Study ID Numbers: CONVINT
First Submitted: October 25, 2010
First Posted: October 26, 2010
Last Update Posted: May 25, 2011
Last Verified: July 2010

Additional relevant MeSH terms:
Renal Insufficiency
Acute Kidney Injury
Kidney Diseases
Urologic Diseases