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Differential Diagnosis of STA-PSV in Thyrotoxicosis

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01227499
Recruitment Status : Completed
First Posted : October 25, 2010
Last Update Posted : May 5, 2014
Zhongda Hospital
Fudan University
Information provided by (Responsible Party):
xiaolong zhao, Huashan Hospital

Brief Summary:
Aim: Graves's disease and thyroiditis can both characterized with thyrotoxicosis, but their clinical outcome and therapy is quiet different. Measurement of iodine uptake is the gold standard to differential diagnosis the thyroiditis or Graves's disease. But the iodine uptake is limited for its availability in china and easily influenced by medicine or food contained iodine.The blood pattern of thyroid CFDS is useful for differentiate the cause of thyrotoxicosis.Most previous studies using the descriptive pattern of thyroid CFDS is easily varied by operator subjective judgement. This study is focus on the role of peak systolic velocity of thyroid superior artery in differential diagnosis of thyrotoxicosis. Methods: Patients with thyrotoxicosis symptoms without recent medicine history were enrolled in two clinical center. Its thyroid function, iodine uptake , CFDS of thyroid and peak systolic velocity of thyroid superior artery is detected. Thyrotoxicosis is defined as TSH level below the low value of normal range. Graves disease is defined as the typical symptoms of graves disease such as graves ophthalmopathy or increased iodine uptake. Thyroiditis is defined as lack of typical symptoms of graves disease or decreased iodine uptake.We use receiver operator curve(ROC) to evaluate its diagnosis value

Condition or disease
Thyrotoxicosis Peak Systolic Velocity of Superior Thyroid Artery Thyroiditis Graves Disease

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Study Type : Observational
Actual Enrollment : 169 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Differential Diagnosis Value of Peak Systolic Velocity of Thyroid Superior Artery Using Color Flow Doppler Sonography in Transient Thyrotoxicosis Caused by Thyroiditis and Graves Disease
Study Start Date : June 2010
Actual Primary Completion Date : November 2011
Actual Study Completion Date : November 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Thyroid Diseases

Primary Outcome Measures :
  1. mean STA-PSV [ Time Frame: 2014-04-07 ]
    the mean STA-PSV

  2. uptake of iodine [ Time Frame: December 1, 2013 ]

Secondary Outcome Measures :
  1. PSV [ Time Frame: December 1, 2013 ]

Other Outcome Measures:
  1. thyroid funciton [ Time Frame: December 1, 2013 ]

Information from the National Library of Medicine

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Ages Eligible for Study:   15 Years to 85 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
primary care clinic

Inclusion Criteria:

  • newly diagnosed without taking any antithyroid drug or beta receptor blocker with TSH level below the lower limits of reference range
  • is willing to be enrolled

Exclusion Criteria:

  • unwilling
  • taking antithyroid drug or beta receptor blocker
  • taking foods or medicine rich in iodine in 8 weeks
  • women with pregnant or lactation

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01227499

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China, Shanghai
Xiaolong Zhao
Shanghai, Shanghai, China, 200040
Sponsors and Collaborators
xiaolong zhao
Zhongda Hospital
Fudan University
Publications of Results:
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Responsible Party: xiaolong zhao, endocrinology department, Huashan Hospital Identifier: NCT01227499    
Other Study ID Numbers: huashan001
First Posted: October 25, 2010    Key Record Dates
Last Update Posted: May 5, 2014
Last Verified: May 2014
Additional relevant MeSH terms:
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Graves Disease
Thyroid Diseases
Endocrine System Diseases
Orbital Diseases
Eye Diseases
Autoimmune Diseases
Immune System Diseases