Nicotine and Brain Imaging Research Study
|ClinicalTrials.gov Identifier: NCT01227343|
Recruitment Status : Completed
First Posted : October 25, 2010
Last Update Posted : July 27, 2018
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||54 participants|
|Official Title:||Sex, GABA and Nicotine: A 1H-MRS Study|
|Actual Study Start Date :||March 2010|
|Actual Primary Completion Date :||November 2016|
|Actual Study Completion Date :||November 2017|
Healthy females who smoke 10-30 cigarettes per day for the past 2 years and meet criteria for nicotine dependence.
Healthy females who do not currently smoke cigarettes.
Healthy males who smoke 10-30 cigarettes per day for the past 2 years and who meet criteria for nicotine dependence.
Male - Non-Smokers CLOSED
WE ARE NO LONGER RECRUITING MALE NON-SMOKERS
- To estimate and compare the impact of smoking on cortical GABA levels in male and female smokers and non-smokers. [ Time Frame: 3-10 weeks ]Preliminary findings suggest that nicotine's effects on cortical GABA levels vary by sex with women experiencing the greatest smoking-induced alterations in cortical GABA levels. We hypothesize that female, but not male, smokers will have reduced cortical GABA levels compared to their non-smoking, sex-matched counterparts.
- To measure occipital cortex GABA concentrations in healthy female smokers across the menstrual cycle and to compare their GABA levels with those from a healthy female non-smoking control group. [ Time Frame: 8 weeks ]
- To determine the impact of 10-14 days of smoking abstinence on cortical GABA concentrations in female smokers. [ Time Frame: 10-14 days ]
Biospecimen Retention: Samples Without DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01227343
|United States, Pennsylvania|
|Penn Center for Women's Behavioral Wellness, University of Pennsylvania School of Medicine|
|Philadelphia, Pennsylvania, United States, 19104|
|Principal Investigator:||Cynthia Neill Epperson, M.D.||University of Pennsylvania|