Nicotine and Brain Imaging Research Study
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|ClinicalTrials.gov Identifier: NCT01227343|
Recruitment Status : Completed
First Posted : October 25, 2010
Last Update Posted : September 28, 2018
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||54 participants|
|Official Title:||Sex, GABA and Nicotine: A 1H-MRS Study|
|Actual Study Start Date :||March 2010|
|Actual Primary Completion Date :||November 2016|
|Actual Study Completion Date :||November 2017|
Healthy females who smoke 10-30 cigarettes per day for the past 2 years and meet criteria for nicotine dependence.
Healthy females who do not currently smoke cigarettes.
Healthy males who smoke 10-30 cigarettes per day for the past 2 years and who meet criteria for nicotine dependence.
Male - Non-Smokers CLOSED
WE ARE NO LONGER RECRUITING MALE NON-SMOKERS
- To estimate and compare the impact of smoking on cortical GABA levels in male and female smokers and non-smokers. [ Time Frame: 3-10 weeks ]Preliminary findings suggest that nicotine's effects on cortical GABA levels vary by sex with women experiencing the greatest smoking-induced alterations in cortical GABA levels. We hypothesize that female, but not male, smokers will have reduced cortical GABA levels compared to their non-smoking, sex-matched counterparts.
- To measure occipital cortex GABA concentrations in healthy female smokers across the menstrual cycle and to compare their GABA levels with those from a healthy female non-smoking control group. [ Time Frame: 8 weeks ]To measure occipital cortex GABA concentrations in healthy female smokers across the menstrual cycle and to compare their GABA levels with those from a healthy female non-smoking control group.
- To determine the impact of 10-14 days of smoking abstinence on cortical GABA concentrations in female smokers. [ Time Frame: 10-14 days ]To determine the impact of 10-14 days of smoking abstinence on cortical GABA concentrations in female smokers.
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01227343
|United States, Pennsylvania|
|Penn Center for Women's Behavioral Wellness, University of Pennsylvania School of Medicine|
|Philadelphia, Pennsylvania, United States, 19104|
|Principal Investigator:||Cynthia Neill Epperson, M.D.||University of Pennsylvania|