Pharmacogenomic Study of Androgenetic Alopecia
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|ClinicalTrials.gov Identifier: NCT01227031|
Recruitment Status : Unknown
Verified October 2010 by Taipei Medical University WanFang Hospital.
Recruitment status was: Not yet recruiting
First Posted : October 22, 2010
Last Update Posted : November 12, 2010
Androgenic alopecia, the common form of hair loss is a highly heritable disorder of considerable social significance affecting around 40% of adult men and women. A variety of genetic and environmental factors are likely to play a role in androgenetic alopecia. Genetic variants in the human androgen receptor gene (AR) have been reported to be associated with AGA in Caucasians. Other genes involved with hair loss also have been found. One of them being a gene on chromosome 3 (3q26). A recent genome-wide association study in 296 individuals with male-pattern baldness and 347 controls had carried out and five SNPs on chromosome 20p11 were found to be highly significant association for AGA (rs2180439 combined P = 2.7 x 10(-15)). No interaction was detected with the X-chromosomal androgen receptor locus, suggesting that the 20p11 locus has a role in a yet-to-be-identified androgen-independent pathway.
The total number of evaluated patients with androgenic alopecia will be at least 300. All patients will be further grouped as good responders or poor responders to conventional medications, such as topical minoxidil and systemic finasteride. Candidate genes potentially involved in gout and its treatment response will be selected from the published literatures; specifically, two resources of candidate genes will be selected: (i) genes which are known to directly link with androgenic alopecia, and (ii) genes are potentially implicated in particular pathways of androgen/estrogen receptors, metabolism and downstream signals, and genes involved in anti-oxidants or hair growth. The SNP genotyping will be performed by MALDI-TOF Mass Spectrometry. Data analysis will be performed by comparing SNPs allele frequency between good responder and poor responder to conventional medications of patients with androgenic alopecia and further comparing to the allele frequency of SNPs in healthy controls. A functional study will also be done to prove the genetic association.
|Condition or disease|
|Study Type :||Observational|
|Estimated Enrollment :||400 participants|
|Observational Model:||Case Control|
|Official Title:||Pharmacogenomic Study of Androgenetic Alopecia|
|Study Start Date :||October 2010|
|Primary Completion Date :||October 2010|
|Estimated Study Completion Date :||July 2011|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01227031
|Contact: Ren-Yu Tsai||886-2-29307930 ext firstname.lastname@example.org|
|Taipei Medical University-Wan Fang Hospital||Not yet recruiting|
|Contact: Ren-Yu Tsai 886-2-29307930 ext 2980 email@example.com|
|Principal Investigator:||Ren-Yu Tsai||Taipei Medical University-Wan Fang Hospital|