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Trial record 51 of 73 for:    "Paroxysmal Nocturnal Hemoglobinuria"

Multicenter Retrospective Analysis About the Clinical Characteristics of Korean Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01224483
Recruitment Status : Unknown
Verified October 2010 by Samsung Medical Center.
Recruitment status was:  Recruiting
First Posted : October 20, 2010
Last Update Posted : October 20, 2010
Information provided by:
Samsung Medical Center

Brief Summary:
Paroxysmal nocturnal hemoglobinuria (PNH) is a hematopoietic stem cell disorder in which unregulated activation of the complement system leads to significant ischemic morbidities with shortened lifespan. Life-threatening thromboembolism (TE) is the most feared complication of PNH, accounting for up to 45% of patient deaths. It is estimated that 40% of PNH patients experience a clinically evident TE and 60% of patients without clinically diagnosed TE demonstrate TE by high-sensitivity MRI, indicating the ongoing thrombotic risk in most patients with PNH. Much of these data come from PNH patients from European descent. To understand the impact of TE in patients with PNH from non-European regions, we performed this study to evaluate the clinical characteristics of Korean patients with PNH.

Condition or disease
Hemoglobinuria, Paroxysmal

Detailed Description:
To evaluate the clinical characteristics in Korean PNH patients

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Study Type : Observational
Estimated Enrollment : 350 participants
Time Perspective: Retrospective
Official Title: Multicenter Retrospective Analysis About the Clinical Characteristics of Korean Patients With PNH
Study Start Date : August 2010
Estimated Primary Completion Date : November 2010
Estimated Study Completion Date : December 2010

Information from the National Library of Medicine

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Ages Eligible for Study:   1 Year and older   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Korean PNH patients: diagnosis confirmed by Ham's test or Flow cytometry

Inclusion Criteria:

  • Diagnosis confirmed by Ham's test or Flow cytometry Patients have any Flow cytometry data

Exclusion Criteria:

  • Patients have no Flow cytometry data

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01224483

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Korea, Republic of
Division of Hematology Oncology, Samsung Medical Center Recruiting
Seoul, Korea, Republic of, 135-710
Contact: Jun Ho Jang, M.D.    82-2-3410-0918   
Sponsors and Collaborators
Samsung Medical Center
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Principal Investigator: Jun Ho Jang, M.D. Samsung Medical Center

Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Jun Ho Jang, Aplastic Working Party, The Korean Society of Hematology Identifier: NCT01224483     History of Changes
Other Study ID Numbers: 2010-02-048
First Posted: October 20, 2010    Key Record Dates
Last Update Posted: October 20, 2010
Last Verified: October 2010

Additional relevant MeSH terms:
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Hemoglobinuria, Paroxysmal
Urination Disorders
Urologic Diseases
Urological Manifestations
Signs and Symptoms
Anemia, Hemolytic
Hematologic Diseases
Myelodysplastic Syndromes
Bone Marrow Diseases