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An Active Approach to Treat Amblyopia: Video Game Play

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ClinicalTrials.gov Identifier: NCT01223716
Recruitment Status : Completed
First Posted : October 19, 2010
Last Update Posted : May 17, 2016
Sponsor:
Collaborator:
National Eye Institute (NEI)
Information provided by (Responsible Party):
Roger Winghong Li, University of California, Berkeley

Brief Summary:
Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast. This study uses psychophysical measures to study neural plasticity in adults with amblyopia.

Condition or disease Intervention/treatment Phase
Amblyopia Behavioral: Perceptual learning Behavioral: Video Game Behavioral: Crossover (Occlusion therapy + Video Game) Not Applicable

Detailed Description:
Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast. Our previous findings (see CITATIONS) show that the adult amblyopic brain is still plastic and malleable, suggesting that active approach is potential useful in treating amblyopia. The goal of this project is to assess the limits and mechanisms of neural plasticity in amblyopic spatial vision. This study uses psychophysical measures to study neural plasticity in adults with amblyopia. Research participants will be asked to play video games with the amblyopic eye for a period of time. A range of visual functions will be monitored during the course of treatment.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 20 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Does Video Game Play Induce Plasticity in the Visual System of Adults With Amblyopia?
Study Start Date : December 2004
Actual Primary Completion Date : December 2009
Actual Study Completion Date : December 2009

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Amblyopia

Arm Intervention/treatment
Experimental: Perceptual learning Behavioral: Perceptual learning
Research participants will be asked to practice a visual discrimination task (e.g. position acuity, contrast sensitivity, stereoacuity etc) in our laboratory for a period of time (2 hrs/day, 5 days/week).
Other Names:
  • vision therapy
  • vision training

Experimental: Video Game Behavioral: Video Game
Research participants will be asked to play "off-the-shelf" video games in our laboratory for a period of time (2 hrs/day, 5 days/week).
Other Names:
  • vision therapy
  • vision training

Experimental: Occlusion Therapy Behavioral: Crossover (Occlusion therapy + Video Game)

Phase 1. Research participants will be required to cover the good eye during the day in order to push the brain to use the amblyopic eye (2 hrs/day, 5 days/week for 2-4 weeks).

Phase 2. Research participants will be required to cover the good eye during the day in order to push the brain to use the amblyopic eye (2 hrs/day, 5 days/week for 2-4 weeks).

Other Names:
  • vision therapy
  • vision training




Primary Outcome Measures :
  1. Amblyopic vision [ Time Frame: 9 months ]
    Improvement in amblyopic vision : visual acuity and stereoacuity


Secondary Outcome Measures :
  1. Spatial vision [ Time Frame: 9 months ]
    Improvement in spatial vision (positional acuity and spatial attention)

  2. Temporal vision [ Time Frame: 9 months ]
    Improvement in temporal processing and temporal vision (attentional blink)



Information from the National Library of Medicine

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Ages Eligible for Study:   5 Years to 75 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Adults with amblyopia (Age >15 years)
  • Amblyopia: interocular visual acuity difference of at least 0.1 logMAR
  • All forms of amblyopia: Strabismic, anisometropic, refractive, deprivative, meridional amblyopia

Exclusion Criteria:

  • Any ocular pathological conditions (eg macula abnormalities, glaucoma), nystagmus

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01223716


Locations
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United States, California
Minor Hall 486, School of Optometry, University of California, Berkeley
Berkeley, California, United States, 94720
Sponsors and Collaborators
University of California, Berkeley
National Eye Institute (NEI)
Investigators
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Principal Investigator: Roger W Li, OD, PhD School of Optometry, Univeristy of california-Berkeley
Principal Investigator: Dennis M Levi, OD, PhD School of Optometry, Univerisity of California-Berkeley

Publications of Results:

Other Publications:
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Responsible Party: Roger Winghong Li, Research Specialist, University of California, Berkeley
ClinicalTrials.gov Identifier: NCT01223716     History of Changes
Other Study ID Numbers: CPHS#2003-11-83
R01EY001728 ( U.S. NIH Grant/Contract )
First Posted: October 19, 2010    Key Record Dates
Last Update Posted: May 17, 2016
Last Verified: May 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided
Keywords provided by Roger Winghong Li, University of California, Berkeley:
amblyopia treatment
neural plasticity
perceptual learning
vision therapy
spatial vision
video games
occlusion therapy
Additional relevant MeSH terms:
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Amblyopia
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vision Disorders
Sensation Disorders
Neurologic Manifestations
Eye Diseases
Signs and Symptoms