The Prevalence of Hearing Loss Among Children With Congenital Hypothyroidism
![]() |
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT01223638 |
Recruitment Status
:
Withdrawn
(written here by mistake)
First Posted
: October 19, 2010
Last Update Posted
: July 8, 2015
|
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Congenital hypothyroidism (CH) occurs in 1:4000 live births. Neurological disturbances like speech delay, motor delay and lower IQ were reported in children with CH. Evidence from animal experiments indicate that CH is associated with high frequency of deafness. Morphological changes of the external and internal cholera hairs were reported in mutagenic mice with CH. Anatomical changes of the internal ear and low hearing threshold were reported in mice bearing Dual oxidase 2 (Duox2) gene mutations, which is responsible of oxidation of iodide. Knockout of Pax8 gene in mice resulted in both agenesis of thyroid gland and deafness. Early L-thyroxin therapy prevented the development of deafness in those mice. The expression of thyroid receptor α (TRα) in the external and internal cholera hairs in mice indicates that the thyroid hormones have an important role in the development of the internal ear.
The etiology of deafness in human is both genetic and environmental. The prevalence of deafness in live births is 1:1000 and among them 60% is genetic. Connexin 26 gene mutations are the most common cause of inherited deafness and account for about 40% of the genetic cases. In two conditions in human the coexistence of hypothyroidism and deafness were reported; Pendred syndrome and thyroid hormone resistance syndrome.
The prevalence of hearing loss in human with CH was explored in only few studies and the results are contrary.
The aim of the current study is to study the prevalence of hearing loss among children with CH and to compare the clinical, biochemical and genetic characteristics between subjects with hearing loss to those without hearing loss.
Condition or disease | Intervention/treatment |
---|---|
Congenital Hypothyroidism Hearing Loss | Other: Audiometry |
Study Type : | Observational |
Actual Enrollment : | 0 participants |
Observational Model: | Case Control |
Time Perspective: | Prospective |
Study Start Date : | September 2010 |
Actual Primary Completion Date : | December 2012 |
Actual Study Completion Date : | June 2015 |
Group/Cohort | Intervention/treatment |
---|---|
Congenital hypothyroidism
Patient which were diagnosed with congenital hypothyroidism
|
Other: Audiometry
Audiometry
|
Controls
Patients without any endocrine or hearing problems
|
Other: Audiometry
Audiometry
|
- Hearing Level [ Time Frame: 2 years ]

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 2 Years to 30 Years (Child, Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Patients with congenital hypothyroidism aged 2-30 years
Exclusion Criteria:
- Hearing defects in the family
- Intrauterine infections
- Perinatal hypoxia
- Long term therapy with aminoglycosides
- Acoustic trauma in the past

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01223638
Israel | |
Ha'Emek Medical Center | |
Afula, Israel, 18101 |
Responsible Party: | Dr. Yardena Tenenbaum - Rakover, HaEmek Medical Center, Israel |
ClinicalTrials.gov Identifier: | NCT01223638 History of Changes |
Other Study ID Numbers: |
0128-08-EMC |
First Posted: | October 19, 2010 Key Record Dates |
Last Update Posted: | July 8, 2015 |
Last Verified: | July 2015 |
Keywords provided by HaEmek Medical Center, Israel:
Congenital hypothyroidism(CH) Hearing loss among children with CH |
Additional relevant MeSH terms:
Hypothyroidism Congenital Hypothyroidism Hearing Loss Deafness Hearing Disorders Ear Diseases Otorhinolaryngologic Diseases Sensation Disorders Neurologic Manifestations Nervous System Diseases |
Signs and Symptoms Thyroid Diseases Endocrine System Diseases Dwarfism Bone Diseases, Developmental Bone Diseases Musculoskeletal Diseases Bone Diseases, Endocrine Genetic Diseases, Inborn |