Effect of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment on Endothelial Function
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 81 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
no prior treatment with statins
age below 18 or above 81 years
serum creatinine > 176μmol/L
total-cholesterol > 7.0 mmol/l
hypothyreoidism ((TSH > 1.5 x ULN (upper limit of normal))
current liver disease (ALAT > 2 x ULN)
unexplained creatine kinase > 3 x ULN
alcohol or drug abuse within the last five years
prior myopathy or serious hypersensitivity reaction caused by statins
women with childbearing potential who were not using chemical or mechanical contraception
pregnant or breastfeeding women
history of malignancy unless a disease-free period of more than five years was present
patients with abnormal lung function test (LFT)
participation in another investigational drug study less than four weeks before enrolment in the present study