Pancreatic Intraepithelial Neoplasia (PanIN) and the Association With Recurrence of Pancreatic Adenocarcinoma
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|ClinicalTrials.gov Identifier: NCT01219829|
Recruitment Status : Active, not recruiting
First Posted : October 13, 2010
Last Update Posted : February 8, 2018
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||5 participants|
|Official Title:||Refining the Molecular Progression From Intraductal to Invasive Pancreatic Cancer: Correlating Genetic Profiles and Clinicopathological Phenotypes in Sporadic and Familial Pancreatic Adenocarcinoma|
|Actual Study Start Date :||March 18, 2009|
|Estimated Primary Completion Date :||July 2019|
|Estimated Study Completion Date :||July 2020|
Family History patients
Patients with a strong family history of pancreatic cancer or with a genetic syndrome that puts them at risk for pancreas cancer.
Patients who underwent surgery for pancreatic cancer and developed tumor recurrence after surgery
- Number of subjects with histological features of PanIN lesions assessed [ Time Frame: 1 year ]Distinctive histological features of PanIN within surgical specimens of our two study groups will be assessed by pathologists.
- Evaluation of clonality multifocal PanIN lesions [ Time Frame: 1 year ]Using microarray-based comparative genomic hybridization (aCGH) to evaluate the samples.
- Evaluation of Recurrence Mechanism in PDC [ Time Frame: 1 year ]aCGH will also be utilized to evaluate recurrence mechanism in a set of cases in which both original tumor and recurrence tumor was resected, allowing for clonal origins to be evaluated.
Biospecimen Retention: Samples With DNA
- Blood samples
- Specimens of tumors, pre-cancerous lesions, and normal tissue from patients who need to have endoscopy or surgery for diagnosis or treatment of tumors that develop
- Samples of urine and stool, and duodenal aspirates if an individual will be having an endoscopy
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01219829
|United States, New York|
|Columbia University Medical Center|
|New York, New York, United States, 10032|
|Principal Investigator:||Wendy K Chung, MD||Columbia University|