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Development of Bone Grafts Using Adipose Derived Stem Cells and Different Scaffolds

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ClinicalTrials.gov Identifier: NCT01218945
Recruitment Status : Completed
First Posted : October 11, 2010
Last Update Posted : June 19, 2013
Sponsor:
Information provided by (Responsible Party):
University of Zurich

Brief Summary:
The repair of large osseous defects remains still unsolved. Aim of this study is to isolate and cultivate fat-derived progenitor cells and differentiation into osteoblasts. Therefore, our research idea is to pre-engineer large synthetic bone grafts and study the vascularization process in vivo.

Condition or disease Intervention/treatment
Overweight Procedure: Cell Culture

Study Type : Observational
Actual Enrollment : 33 participants
Time Perspective: Prospective
Official Title: Development of Bone Grafts Using Adipose Derived Stem Cells and Different Scaffolds: Impact of Pre-engineered Capillaries in Critical Size Grafts
Study Start Date : November 2009
Actual Primary Completion Date : December 2012
Actual Study Completion Date : December 2012

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Bone Grafts
U.S. FDA Resources

Group/Cohort Intervention/treatment
Fat Removal
Patients undergoing surgical fat removal
Procedure: Cell Culture
Aim of this study is to isolate and cultivate fat-derived progenitor cells and differentiation into osteoblasts. Therefore, our research idea is to pre-engineer large synthetic bone grafts and study the vascularization process in vivo.



Biospecimen Retention:   Samples With DNA
Human adipose-derived stem cells from human fat


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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients admitted for reconstructive surgery
Criteria

Inclusion criteria:

  • German-speaking patients aged 18-70 admitted to the Clinic of Reconstructive surgery for reconstructive surgery and fat-excision.

Exclusion criteria:

  • Drug-abuse, neoplasia and metabolic disorders

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01218945


Locations
Switzerland
University Hospital Zurich, Clinic of Reconstructive Surgery
Zurich, ZH, Switzerland, 8091
Sponsors and Collaborators
University of Zurich
Investigators
Principal Investigator: Maurizio Calcagni, MD University Hospital Zurich, Clinic of Reconstructive Surgery

Responsible Party: University of Zurich
ClinicalTrials.gov Identifier: NCT01218945     History of Changes
Other Study ID Numbers: Bone-ZH09
First Posted: October 11, 2010    Key Record Dates
Last Update Posted: June 19, 2013
Last Verified: June 2013

Additional relevant MeSH terms:
Overweight
Body Weight
Signs and Symptoms