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The Neural Correlates of Food Choice Decision-making in Obesity and Weight Loss (CHOICES)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified July 2013 by The Miriam Hospital.
Recruitment status was:  Recruiting
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
California Institute of Technology
Information provided by (Responsible Party):
Kathryn E. Demos, The Miriam Hospital Identifier:
First received: October 7, 2010
Last updated: July 25, 2013
Last verified: July 2013
This study is designed to determine whether obese, normal weight, and successful weight loss maintainers differ in their food choice decision-making and/or executive function, and whether participation in a behavioral weight loss program leads to neural and/or behavioral changes. The investigators will examine behavioral performance on several tasks involving decision-making and self-control in conjunction with brain imaging data acquired during a food-choice decision-making task. Participants enrolled in the behavioral weight loss program will also be assessed following the treatment.

Condition Intervention
Weight Loss
Weight Control
Behavioral: CHOICES - obese

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: The Neural Correlates of Food Choice Decision-making in Obesity and Weight Loss (CHOICES)

Resource links provided by NLM:

Further study details as provided by The Miriam Hospital:

Primary Outcome Measures:
  • fMRI [ Time Frame: pre- and post-treatment in obese group, single time point for SWLM and NW ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Behavioral data [ Time Frame: pre- and post-treatment of obese group, single time point for SWLM and NW ] [ Designated as safety issue: No ]

Estimated Enrollment: 90
Study Start Date: March 2010
Estimated Study Completion Date: October 2016
Estimated Primary Completion Date: October 2016 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: CHOICES - obese
behavioral weight loss treatment - overweight/obese females
Behavioral: CHOICES - obese
Standard group behavioral weight loss treatment


Ages Eligible for Study:   35 Years to 55 Years   (Adult)
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • women, ages 35-55, who are either currently obese (BMI = 30-40 kg/m2), always normal weight (lifetime BMI < 25, NW) or successful weight loss maintainers who have lost 10% of their body weight and maintained that loss for at least 1 year (lifetime maximum BMI = 30-40 kg/m2)

Exclusion Criteria:

  • weight loss medications, binge eating, standard MRI contraindications (e.g., metal implants, claustrophobia, pregnancy), left-handedness, food allergies, neurological or psychiatric conditions, including but not limited to schizophrenia, bipolar disorder, epilepsy, stroke and traumatic brain injury with loss of consciousness, and, among obese participants, inability to participate at two time points and lack of interest in participating in a behavioral weight loss trial
  • serious current physical disease (e.g., heart disease and cancer) for which physician supervision of diet and exercise prescription is needed, physical problems that limit the ability to exercise, participation in a weight loss program in the last 2 months and intention to become pregnant in the next 6 months
  Contacts and Locations
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Please refer to this study by its identifier: NCT01218503

United States, Rhode Island
Weight Control & Diabetes Research Center
Providence, Rhode Island, United States, 02903
Sponsors and Collaborators
The Miriam Hospital
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
California Institute of Technology
  More Information

Responsible Party: Kathryn E. Demos, Assistant Professor (Research), The Miriam Hospital Identifier: NCT01218503     History of Changes
Other Study ID Numbers: BRAIN-T32  K01DK090445 
Study First Received: October 7, 2010
Last Updated: July 25, 2013
Health Authority: United States: Institutional Review Board

Additional relevant MeSH terms:
Body Weight
Weight Loss
Nutrition Disorders
Signs and Symptoms
Body Weight Changes processed this record on January 17, 2017