Methylprednisolone Pulse Macrolide Therapy for Refractory Mycoplasma Pneumoniae Pneumonia in Children (MPP)
|ClinicalTrials.gov Identifier: NCT01217099|
Recruitment Status : Terminated (terminated)
First Posted : October 8, 2010
Last Update Posted : October 8, 2010
|Condition or disease||Intervention/treatment||Phase|
|Refractory Mycoplasma Pneumoniae Pneumonia||Drug: methylprednisolone Drug: azithromycin||Not Applicable|
Corticosteroid has been used in adulthood refractory MPP with satisfactory efficacy. But there were few studies about the use of corticosteroid in children with refractory MPP. Lee KY et al indicated oral prednisolone of 1 mg/kg/ day for 1 week be useful for children with severe MPP. Akihiro T et al demonstrated that intravenously administered methylprednisolone at a dose of 30 mg/kg once daily for 3 consecutive days had an efficacious treatment for children with refractory MPP.But the methods of corticosteroid use, such as the dosage, administration route, duration of treatment have not been well understood. So in this study, we planned to investigate whether small doses of methylprednisolone pulse macrolide therapy can relieve symptoms,chest X-rays faster than macrolide alone therapy for refractory mycoplasma pneumoniae pneumonia in a prospective, open-label fashion.
PMID: 11096025 PMID: 18033831 PMID: 10434547 PMID: 16437541 PMID: 18656264
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||47 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||A Prospective, Open-label Trial of Methylprednisolone Pulse Macrolide Therapy for Refractory Mycoplasma Pneumoniae Pneumonia in Children|
|Study Start Date :||May 2007|
|Actual Primary Completion Date :||May 2010|
|Actual Study Completion Date :||May 2010|
No Intervention: methylprednisolone
methylprednisolone pulse azithromycin
treatment patients were iv methylprednisolone pulse azithromycin for 5 days.
Other Name: treatment group
No Intervention: azithromycin
control patients were iv azithromycin for 5 days.
Other Name: control group
- efficacy of methylprednisolone pulse macrolide therapy for children with refractory MPP. [ Time Frame: 3-year ]compare the temperature , infiltration absorption,atelectasis resolution, pleural effusion disappearance,serum levels of ferritin and LDH between methylprednisolone pulse macrolide therapy group and macrolide therapy group .
- safety of methylprednisolone pulse macrolide therapy for children with refractory MPP. [ Time Frame: 3-year ]observe the further complications of infection between methylprednisolone pulse macrolide therapy group and macrolide therapy group .
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01217099
|Principal Investigator:||zhengxiu luo, doctor||Chongqing Medical University|