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Oxytocin and Emotion Recognition

This study has been completed.
Information provided by:
University Hospital Freiburg Identifier:
First received: October 6, 2010
Last updated: NA
Last verified: October 2010
History: No changes posted
The present study was designed to investigate the effects of a single dose of synthetic oxytocin on facial emotion recognition in healthy adult man. Pictures of emotional faces are presented very briefly for a few milliseconds in a backward-masking paradigm in order to vary the level of awareness. In a randomized placebo-controlled between-subject design, recognition performance is compared between a drug (24 IU oxytocin) and a placebo condition. We hypothesize that oxytocin enhances emotion recognition even for facial stimuli processed with limited awareness.

Condition Intervention Phase
Health Drug: Syntocinon 24 IU Drug: Placebo Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Basic Science

Resource links provided by NLM:

Further study details as provided by University Hospital Freiburg:

Primary Outcome Measures:
  • Performance on a facial emotion recognition task [ Time Frame: 45 min. following drug administration ]

Enrollment: 56
Study Start Date: November 2009
Study Completion Date: January 2010
Primary Completion Date: January 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Oxytocin Drug: Syntocinon 24 IU
Placebo Comparator: Placebo Drug: Placebo


Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Males
  • 18 to 40 years of age

Exclusion Criteria:

  • Any psychiatric diagnosis life-time
  • Somatic disease
  • IQ < 85
  • Smoker
  • Psychoactive medication
  Contacts and Locations
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Please refer to this study by its identifier: NCT01216605

Department of PSychiatry University of Rostock
Rostock, D, Germany, 18055
Sponsors and Collaborators
University Hospital Freiburg
Principal Investigator: Gregor Domes, PhD University of Freiburg
  More Information Identifier: NCT01216605     History of Changes
Other Study ID Numbers: X01A-DO1312/1-1
DO1312/1-1 ( Other Grant/Funding Number: German Research Foundation (DFG) )
Study First Received: October 6, 2010
Last Updated: October 6, 2010

Additional relevant MeSH terms:
Reproductive Control Agents
Physiological Effects of Drugs processed this record on June 23, 2017