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Involvement of Translation Initiation Factors in the Immune Response in the Elderly

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified March 2012 by Meir Medical Center.
Recruitment status was:  Recruiting
Information provided by (Responsible Party):
Meir Medical Center Identifier:
First received: October 5, 2010
Last updated: March 16, 2012
Last verified: March 2012

The investigators propose that the translation initiation factors eIF4E and eIF4GI may be involved in resolution of acute inflammation (regardless of age). Furthermore, the investigators suggest that differences in translation initiation factors state of activation may contribute to inflammation. Finally, the investigators hypothesize that differences in translation initiation factors state of activation may underlie the immune compromised state of the very elderly affording additional explanation for the heightened morbidity from infection in this group.

In the current study the investigators aim to test these hypotheses by measuring the levels of eIF4E and eIF4G, their regulators, and targets in elderly (65-84yrs) and very elderly (85yrs<) patients hospitalized at Meir hospital for acute infection and after their recovery (detailed in study design).

Elderly Patient

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Characterization of the Involvement of Translation Initiation Factors in the Immune Response to Acute Infection in the Elderly and Very Elderly

Further study details as provided by Meir Medical Center:

Biospecimen Retention:   Samples With DNA
Blood samples of elderly patients diagnosed with acute infection will be collected at admittance to Meir hospital and on recovery (24-48 hours without fever and leukocytosis)

Estimated Enrollment: 40
Study Start Date: October 2010
Estimated Study Completion Date: October 2012
Primary Completion Date: October 2011 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   65 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
patient aged >65 years admitted to internal medicine or geriatric departments due to acute infection with fever and leukocytosis.

Inclusion Criteria:

  • elderly patients (65<)
  • hospitalized for acute infection (fever 38c<, leukocytosis)

Exclusion Criteria:

  • patients with dementia who can not sign informed consent of institutional Helsinki committee
  • patient with active cancer with active chemotherapy treatment
  Contacts and Locations
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Please refer to this study by its identifier: NCT01215604

Meir Medical Center Recruiting
Kfar Sava, Israel
Contact: Racheli Heffez, MD    972-9-7472181   
Principal Investigator: rachel Heffez Ayzenfeld, MD         
Sponsors and Collaborators
Meir Medical Center
Principal Investigator: Rachel Heffez Ayzenfeld, MD Meir Medical Center
  More Information

Responsible Party: Meir Medical Center Identifier: NCT01215604     History of Changes
Other Study ID Numbers: MMC10156-2010CTIL
Study First Received: October 5, 2010
Last Updated: March 16, 2012

Keywords provided by Meir Medical Center:
elderly patients
acute infection
translation initiation factors

Additional relevant MeSH terms:
Infection processed this record on May 24, 2017