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Involvement of Translation Initiation Factors in the Immune Response in the Elderly

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified March 2012 by Meir Medical Center.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01215604
First Posted: October 6, 2010
Last Update Posted: March 19, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Meir Medical Center
  Purpose

The investigators propose that the translation initiation factors eIF4E and eIF4GI may be involved in resolution of acute inflammation (regardless of age). Furthermore, the investigators suggest that differences in translation initiation factors state of activation may contribute to inflammation. Finally, the investigators hypothesize that differences in translation initiation factors state of activation may underlie the immune compromised state of the very elderly affording additional explanation for the heightened morbidity from infection in this group.

In the current study the investigators aim to test these hypotheses by measuring the levels of eIF4E and eIF4G, their regulators, and targets in elderly (65-84yrs) and very elderly (85yrs<) patients hospitalized at Meir hospital for acute infection and after their recovery (detailed in study design).


Condition
Elderly Patient Infection

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Characterization of the Involvement of Translation Initiation Factors in the Immune Response to Acute Infection in the Elderly and Very Elderly

Further study details as provided by Meir Medical Center:

Biospecimen Retention:   Samples With DNA
Blood samples of elderly patients diagnosed with acute infection will be collected at admittance to Meir hospital and on recovery (24-48 hours without fever and leukocytosis)

Estimated Enrollment: 40
Study Start Date: October 2010
Estimated Study Completion Date: October 2012
Primary Completion Date: October 2011 (Final data collection date for primary outcome measure)
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   65 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
patient aged >65 years admitted to internal medicine or geriatric departments due to acute infection with fever and leukocytosis.
Criteria

Inclusion Criteria:

  • elderly patients (65<)
  • hospitalized for acute infection (fever 38c<, leukocytosis)

Exclusion Criteria:

  • patients with dementia who can not sign informed consent of institutional Helsinki committee
  • patient with active cancer with active chemotherapy treatment
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01215604


Locations
Israel
Meir Medical Center Recruiting
Kfar Sava, Israel
Contact: Racheli Heffez, MD    972-9-7472181    rachelhe2@clalit.org.il   
Principal Investigator: rachel Heffez Ayzenfeld, MD         
Sponsors and Collaborators
Meir Medical Center
Investigators
Principal Investigator: Rachel Heffez Ayzenfeld, MD Meir Medical Center
  More Information

Responsible Party: Meir Medical Center
ClinicalTrials.gov Identifier: NCT01215604     History of Changes
Other Study ID Numbers: MMC10156-2010CTIL
First Submitted: October 5, 2010
First Posted: October 6, 2010
Last Update Posted: March 19, 2012
Last Verified: March 2012

Keywords provided by Meir Medical Center:
elderly patients
acute infection
translation initiation factors
eIF4E
eIF4G

Additional relevant MeSH terms:
Infection