Involvement of Translation Initiation Factors in the Immune Response in the Elderly
|ClinicalTrials.gov Identifier: NCT01215604|
Recruitment Status : Unknown
Verified March 2012 by Meir Medical Center.
Recruitment status was: Recruiting
First Posted : October 6, 2010
Last Update Posted : March 19, 2012
The investigators propose that the translation initiation factors eIF4E and eIF4GI may be involved in resolution of acute inflammation (regardless of age). Furthermore, the investigators suggest that differences in translation initiation factors state of activation may contribute to inflammation. Finally, the investigators hypothesize that differences in translation initiation factors state of activation may underlie the immune compromised state of the very elderly affording additional explanation for the heightened morbidity from infection in this group.
In the current study the investigators aim to test these hypotheses by measuring the levels of eIF4E and eIF4G, their regulators, and targets in elderly (65-84yrs) and very elderly (85yrs<) patients hospitalized at Meir hospital for acute infection and after their recovery (detailed in study design).
|Condition or disease|
|Elderly Patient Infection|
|Study Type :||Observational|
|Estimated Enrollment :||40 participants|
|Official Title:||Characterization of the Involvement of Translation Initiation Factors in the Immune Response to Acute Infection in the Elderly and Very Elderly|
|Study Start Date :||October 2010|
|Actual Primary Completion Date :||October 2011|
|Estimated Study Completion Date :||October 2012|
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01215604
|Meir Medical Center||Recruiting|
|Kfar Sava, Israel|
|Contact: Racheli Heffez, MD 972-9-7472181 email@example.com|
|Principal Investigator: rachel Heffez Ayzenfeld, MD|
|Principal Investigator:||Rachel Heffez Ayzenfeld, MD||Meir Medical Center|