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Isolation and Authentication of Mesenchymal Stem Cell-like Progenitor Cells From the Degenerated Intervertebral Disc of Lumbar Spine

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ClinicalTrials.gov Identifier: NCT01213953
Recruitment Status : Unknown
Verified October 2010 by Taipei Medical University WanFang Hospital.
Recruitment status was:  Active, not recruiting
First Posted : October 4, 2010
Last Update Posted : October 19, 2010
Sponsor:
Information provided by:
Taipei Medical University WanFang Hospital

Brief Summary:
The study is designed for evaluating the presence of mesenchymal stem cells of vertebral disc. Isolation and authentication of these cells may be applied for the vertebral disc regeneration and the research tissue engineering.

Condition or disease
Lower Back Pain Disc Degeneration

Detailed Description:
We will collect the degenerative disc from adults and isolate the mesenchymal stem cell-like precursors cells. The function of osteogenic, chondrogenic, and lipogenic differentiation will be authenticated. The results will offer the information for cell source of tissue engineering in the future.

Study Type : Observational
Estimated Enrollment : 20 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Isolation and Authentication of Mesenchymal Stem Cell-like Progenitor Cells From the Degenerated Intervertebral Disc of Lumbar Spine
Study Start Date : September 2010
Estimated Primary Completion Date : October 2011
Estimated Study Completion Date : December 2011

Resource links provided by the National Library of Medicine

U.S. FDA Resources




Biospecimen Retention:   Samples Without DNA
The biospecimen is the tissue waste after the surgery of discectomy.


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Ages Eligible for Study:   20 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
The patients received the surgery of discectomy for the degenerative disc.
Criteria

Inclusion Criteria:

  • The adults with disc degeneration(age >= 20 years old) A. Herniated intervertebral disc. B. Spondylolisthesis. C. Spondylolysis. D. Other causes of disc degeneration.

Exclusion Criteria:

  • Age < 20 years old.
  • Pregnancy.
  • Spinal tumors.
  • Spinal infections.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01213953


Locations
Taiwan
Taipei Medical University - WanFang Hospital
Taipei, Taiwan
Sponsors and Collaborators
Taipei Medical University WanFang Hospital
Investigators
Principal Investigator: Hsieh-Hsing Lee Taipei Medical University Shuang Ho Hospital

Responsible Party: Hsieh-Hsing Lee, Department of Orthopedics, Shuang Ho Hospital, Taipei Medical University
ClinicalTrials.gov Identifier: NCT01213953     History of Changes
Other Study ID Numbers: 98025
First Posted: October 4, 2010    Key Record Dates
Last Update Posted: October 19, 2010
Last Verified: October 2010

Keywords provided by Taipei Medical University WanFang Hospital:
Vertebral disc, mesenchymal stem cell.

Additional relevant MeSH terms:
Back Pain
Low Back Pain
Intervertebral Disc Degeneration
Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Spinal Diseases
Bone Diseases
Musculoskeletal Diseases