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Isolation and Authentication of Mesenchymal Stem Cell-like Progenitor Cells From the Degenerated Intervertebral Disc of Lumbar Spine

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified October 2010 by Taipei Medical University WanFang Hospital.
Recruitment status was:  Active, not recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01213953
First Posted: October 4, 2010
Last Update Posted: October 19, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Taipei Medical University WanFang Hospital
  Purpose
The study is designed for evaluating the presence of mesenchymal stem cells of vertebral disc. Isolation and authentication of these cells may be applied for the vertebral disc regeneration and the research tissue engineering.

Condition
Lower Back Pain Disc Degeneration

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Isolation and Authentication of Mesenchymal Stem Cell-like Progenitor Cells From the Degenerated Intervertebral Disc of Lumbar Spine

Resource links provided by NLM:


Further study details as provided by Taipei Medical University WanFang Hospital:

Biospecimen Retention:   Samples Without DNA
The biospecimen is the tissue waste after the surgery of discectomy.

Estimated Enrollment: 20
Study Start Date: September 2010
Estimated Study Completion Date: December 2011
Estimated Primary Completion Date: October 2011 (Final data collection date for primary outcome measure)
Detailed Description:
We will collect the degenerative disc from adults and isolate the mesenchymal stem cell-like precursors cells. The function of osteogenic, chondrogenic, and lipogenic differentiation will be authenticated. The results will offer the information for cell source of tissue engineering in the future.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
The patients received the surgery of discectomy for the degenerative disc.
Criteria

Inclusion Criteria:

  • The adults with disc degeneration(age >= 20 years old) A. Herniated intervertebral disc. B. Spondylolisthesis. C. Spondylolysis. D. Other causes of disc degeneration.

Exclusion Criteria:

  • Age < 20 years old.
  • Pregnancy.
  • Spinal tumors.
  • Spinal infections.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01213953


Locations
Taiwan
Taipei Medical University - WanFang Hospital
Taipei, Taiwan
Sponsors and Collaborators
Taipei Medical University WanFang Hospital
Investigators
Principal Investigator: Hsieh-Hsing Lee Taipei Medical University Shuang Ho Hospital
  More Information

Responsible Party: Hsieh-Hsing Lee, Department of Orthopedics, Shuang Ho Hospital, Taipei Medical University
ClinicalTrials.gov Identifier: NCT01213953     History of Changes
Other Study ID Numbers: 98025
First Submitted: October 1, 2010
First Posted: October 4, 2010
Last Update Posted: October 19, 2010
Last Verified: October 2010

Keywords provided by Taipei Medical University WanFang Hospital:
Vertebral disc, mesenchymal stem cell.

Additional relevant MeSH terms:
Back Pain
Low Back Pain
Intervertebral Disc Degeneration
Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Spinal Diseases
Bone Diseases
Musculoskeletal Diseases