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Utility of Brain Natriuretic Peptide (BNP) in Patients With Type IV Cardio-renal Syndrome Admitted to the Intensive Care Unit (ICU)

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ClinicalTrials.gov Identifier: NCT01211886
Recruitment Status : Unknown
Verified September 2010 by Hallym University Medical Center.
Recruitment status was:  Not yet recruiting
First Posted : September 30, 2010
Last Update Posted : October 5, 2011
Information provided by (Responsible Party):
Hallym University Medical Center

Brief Summary:
Admission BNP was a useful marker for diagnosing and predicting type IV cardio-renal syndrome type IV in patients with chronic kidney disease admitted to the ICU for acute heart failure in a retrospective study. Therefore, we aim to prospectively investigate the utility of serum BNP in evaluating the treatment adequacy and predicting future cardiac events in patients with type IV CRS.

Condition or disease
Chronic Kidney Disease Acute Heart Failure

Study Type : Observational
Estimated Enrollment : 83 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Utility of BNP in Patients With Type IV Cardio-renal Syndrome Admitted to the ICU: a Prospective Observational Study
Study Start Date : September 2010
Estimated Primary Completion Date : August 2012

Biospecimen Retention:   Samples Without DNA
Serum sample for BNP level

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with chronic kidney disease admitted to the ICU for acute heart failure (i.e., type IV cardio-renal syndrome)

Inclusion Criteria:

  • Adult patients aged > 18 years, Patients with chronic kidney disease (Serum Cr > 2.0, Documented medical history of chronic kidney disease

Exclusion Criteria:

  • Cardiopulmonary resuscitation, Do-not-resuscitate state, Acute kidney injury, ICU stay < 1 day

Responsible Party: Hallym University Medical Center
ClinicalTrials.gov Identifier: NCT01211886     History of Changes
Other Study ID Numbers: f2000tj1
First Posted: September 30, 2010    Key Record Dates
Last Update Posted: October 5, 2011
Last Verified: September 2010

Keywords provided by Hallym University Medical Center:
Brain natriuretic peptide
Cardio-renal syndrome

Additional relevant MeSH terms:
Heart Failure
Kidney Diseases
Renal Insufficiency, Chronic
Cardio-Renal Syndrome
Heart Diseases
Cardiovascular Diseases
Urologic Diseases
Renal Insufficiency
Natriuretic Peptide, Brain
Natriuretic Agents
Physiological Effects of Drugs