Target Planning for Placement of DBS-electrodes and Follow-up of the Clinical Efficacy of Stimulation
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ClinicalTrials.gov Identifier: NCT01210781 |
Recruitment Status
:
Enrolling by invitation
First Posted
: September 28, 2010
Last Update Posted
: May 30, 2016
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Deep brain stimulation (DBS) has been established as therapy for severe forms of Parkinson's disease and other indications. A common target for stimulation is the subthalamic nucleus (STN). Nevertheless, there is no agreement on the mechanisms how DBS leads to clinical improvement.
The project aims to describe the variability of target coordinates in the patient group and to relate it to clinical outcome as documented in standardized questionaires.
- Trial with surgical intervention
Condition or disease | Intervention/treatment |
---|---|
Movement Disorders Epilepsy | Procedure: deep brain stimulation (DBS) |
Deep brain stimulation (DBS) has been established as therapy for severe forms of Parkinson's disease and other indications. A common target for stimulation is the subthalamic nucleus (STN). Nevertheless, there is no agreement on the mechanisms how DBS leads to clinical improvement.
The project aims to describe the variability of target coordinates in the patient group and to relate it to clinical outcome as documented in standardized questionaires.
Study Type : | Observational |
Estimated Enrollment : | 100 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | Target Planning for Placement of DBS-electrodes and Follow-up of the Clinical Efficacy of Stimulation |
Study Start Date : | September 2009 |
Estimated Primary Completion Date : | December 2020 |
Estimated Study Completion Date : | December 2020 |

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Procedure: deep brain stimulation (DBS)
- neurological outcome [ Time Frame: 5 years ]UPDRS

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Ages Eligible for Study: | 18 Years to 90 Years (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion criteria:
- Patients fullfill all criteria for implantation of deep brain stimulation (DBS) electrodes
- Patients are able to give informed written consent
Exclusion criteria:
- Patients do not their give informed written consent

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01210781
Switzerland | |
University Hospital Zurich, Neurosurgery | |
Zurich, ZH, Switzerland, 8091 |
Principal Investigator: | Johannes Sarnthein, MD | University Hospital Zurich, Division of Neurosurgery |
Responsible Party: | University of Zurich |
ClinicalTrials.gov Identifier: | NCT01210781 History of Changes |
Other Study ID Numbers: |
DBS |
First Posted: | September 28, 2010 Key Record Dates |
Last Update Posted: | May 30, 2016 |
Last Verified: | May 2016 |
Keywords provided by University of Zurich:
All indication for deep brain stimulation (DBS) |
Additional relevant MeSH terms:
Movement Disorders Central Nervous System Diseases Nervous System Diseases |