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Retinal Vascular Reactivity in Subjects With Newly Diagnosed Glaucoma Before and After Selective Laser Trabeculoplasty

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01209975
Recruitment Status : Unknown
Verified September 2010 by University of Toronto.
Recruitment status was:  Recruiting
First Posted : September 28, 2010
Last Update Posted : September 28, 2010
University of Western Ontario, Canada
Information provided by:
University of Toronto

Brief Summary:
The purpose of this study is to assess retinal blood flow and vascular reactivity in patients with newly diagnosed primary open angle glaucoma pre- and post-primary Selective Laser Trabeculoplasty(SLT). Canon Laser Blood Flowmeter will be used for the assessment of retinal blood flow.

Condition or disease Intervention/treatment
Glaucoma Procedure: Selective Laser Trabeculoplasty

Detailed Description:
We previously found that vascular reactivity improved after short term treatment with dorzolamide drops. It is not clear whether this improvement was a direct effect of the medication or secondary effect of the decrease in IOP. We would like to see the change of vascular reactivity before and after SLT, which will decrease the intraocular pressure without pharmacologic effect.

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Study Type : Observational
Estimated Enrollment : 12 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Retinal Vascular Reactivity in Response to Isoxic Hypercapnia in Subjects With Newly Diagnosed Glaucoma
Study Start Date : November 2008
Estimated Primary Completion Date : November 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Glaucoma

Group/Cohort Intervention/treatment
untreated glaucoma patients
We will evaluate the blood flow before and after Selective Laser Trabeculoplasty in patients with primary open angel glaucoma.
Procedure: Selective Laser Trabeculoplasty
Patient will have selective laser trabeculoplasty as the first treatment for glaucoma. This treatment will be dictated clinically, since we do not assign the interventions.

Primary Outcome Measures :
  1. blood flow [ Time Frame: before and two-week after SLT ]
    The Canon Laser Blood Flowmetry will be used to assess the retinal blood flow.

Secondary Outcome Measures :
  1. Intraocuclar pressure [ Time Frame: before and two-week after SLT ]
    Intraocular pressure (IOP) will be measured by Goldmann applanation tonometry.

Information from the National Library of Medicine

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Ages Eligible for Study:   40 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
patient with untreated primary open angle glaucoma

Inclusion Criteria:

  1. Age 40-75 years (Male or Female)
  2. Best corrected visual acuity of at least 20/40
  3. No previous treatment for glaucoma
  4. Ametropia less than ±6.0 DS and ±2.5 DC)
  5. Non-smoker
  6. No cardiovascular/respiratory disorders

Exclusion Criteria:

  1. Past history of diabetes and cerebrovascular accident
  2. Vascular occlusive disease affecting the ocular circulation such as: diabetic retinopathy, retinal vein occlusion and retinal artery occlusion
  3. Previous intraocular surgery
  4. Ocular media opacities limiting the use of the imaging tests

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01209975

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Contact: Tien Wong 416-603-5694

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Canada, Ontario
Toronto Western Hospital Recruiting
Toronto, Ontario, Canada, M5T2S8
Contact: Tien Wong    416-603-5694   
Sponsors and Collaborators
University of Toronto
University of Western Ontario, Canada
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Principal Investigator: Chris Hudson, PhD University of Toronto

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Responsible Party: Dr. Chris Hudson, Department of Ophthalmology and Vision Science Identifier: NCT01209975     History of Changes
Other Study ID Numbers: SLT-blood flow study
First Posted: September 28, 2010    Key Record Dates
Last Update Posted: September 28, 2010
Last Verified: September 2010

Keywords provided by University of Toronto:
blood flow

Additional relevant MeSH terms:
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Ocular Hypertension
Eye Diseases