Combined Approach to Resection of Glioblastoma (GBM) by 5-Aminolevulinic Acid (5-ALA) and Intraoperative Magnetic Resonance Imaging (MRI)
Recruitment status was Recruiting
In the treatment of glioblastoma (GBM) neurosurgical resection of the tumor is usually considered a a first step of effective therapy. Radical resection of the tumor is highly beneficial to the patient as measured in progression-free survival and overall survival. At the same time eloquent areas of the brain have to remain intact to preserve quality of life.
Both 5-ALA fluorescence and intraoperative MRI are used for intraoperative marking of tumor tissue and thereby to improve precision of GBM-Resection.
We now study whether the combination of 5-ALA fluorescence and intraoperative MRI increases the number of sites where tumor tissue can be detected.
- Trial with surgical intervention
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Combined Approach to GBM-resection by 5-ALA and Intraoperative MRI|
tumor samples for pathophysiology
|Study Start Date:||August 2009|
|Estimated Study Completion Date:||December 2011|
|Estimated Primary Completion Date:||December 2011 (Final data collection date for primary outcome measure)|
Procedure: diagnostic 5-ALA and MRI for tumor resection
Precision of GBM-Resection Intraoperative marking of tumor tissue Combination of 5-ALA fluorescence and intraoperative MRI
Please refer to this study by its ClinicalTrials.gov identifier: NCT01208909
|Contact: René L. Bernays, MD||+41 (0)44 255 11 11|
|Contact: René L Bernays, MD +41 44 25 ext 5111|
|Study Director:||René L Bernays, MD||UniversitaetsSpital Zuerich|